Literature DB >> 27835800

Contribution of heteromerization to G protein-coupled receptor function.

Supriya A Gaitonde1, Javier González-Maeso2.   

Abstract

G protein-coupled receptors (GPCRs) are a remarkably multifaceted family of transmembrane proteins that exert a variety of physiological effects. Although family A GPCRs are able to operate as monomers, there is increasing evidence that heteromerization represents a fundamental aspect of receptor function, trafficking and pharmacology. Most recently, it has been suggested that GPCR heteromers may play a crucial role as new molecular targets of heteromer-selective and bivalent ligands. The current review summarizes key recent developments in these topics. Published by Elsevier Ltd.

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Year:  2016        PMID： 27835800      PMCID： PMC5395348          DOI： 10.1016/j.coph.2016.10.006

Source DB:  PubMed          Journal:  Curr Opin Pharmacol        ISSN： 1471-4892            Impact factor:   5.547


  90 in total

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