Michele Herneisey1, Jonathan Williams1, Janja Mirtic2, Lu Liu1, Sneha Potdar1, Christina Bagia1, Jane E Cavanaugh1, Jelena M Janjic1,3,4. 1. Graduate School of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA. 2. Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia. 3. Chronic Pain Research Consortium, Duquesne University, Pittsburgh, PA 15282, USA. 4. McGowan Institute for Regenerative Medicine, University of Pittsburgh, PA 15219, USA.
Abstract
AIM: Delivery of the natural anti-inflammatory compound resveratrol with nanoemulsions can dramatically improve its tissue targeting, bioavailability and efficacy. Current assessment of resveratrol delivery efficacy is limited to indirect pharmacological measures. Molecular imaging solves this problem. Results/methodology: Nanoemulsions containing two complementary imaging agents, near-infrared dye and perfluoropolyether (PFPE), were developed and evaluated. Nanoemulsion effects on macrophage uptake, toxicity and NO production were also evaluated. The presence of PFPE did not affect nanoemulsion size, zeta potential, colloidal stability, drug loading or drug release. CONCLUSION: PFPE nanoemulsions can be used in future studies to evaluate nanoemulsion biodistribution without interfering with resveratrol delivery and pharmacological outcomes. Developed nanoemulsions show promise as a versatile treatment strategy for cancer and other inflammatory diseases. [Formula: see text].
AIM: Delivery of the natural anti-inflammatory compound resveratrol with nanoemulsions can dramatically improve its tissue targeting, bioavailability and efficacy. Current assessment of resveratrol delivery efficacy is limited to indirect pharmacological measures. Molecular imaging solves this problem. Results/methodology: Nanoemulsions containing two complementary imaging agents, near-infrared dye and perfluoropolyether (PFPE), were developed and evaluated. Nanoemulsion effects on macrophage uptake, toxicity and NO production were also evaluated. The presence of PFPE did not affect nanoemulsion size, zeta potential, colloidal stability, drug loading or drug release. CONCLUSION: PFPE nanoemulsions can be used in future studies to evaluate nanoemulsion biodistribution without interfering with resveratrol delivery and pharmacological outcomes. Developed nanoemulsions show promise as a versatile treatment strategy for cancer and other inflammatory diseases. [Formula: see text].
Authors: Ketan R Patel; Edwina Scott; Victoria A Brown; Andreas J Gescher; William P Steward; Karen Brown Journal: Ann N Y Acad Sci Date: 2011-01 Impact factor: 5.691
Authors: Kiran Vasudeva; Karl Andersen; Bree Zeyzus-Johns; T Kevin Hitchens; Sravan Kumar Patel; Anthony Balducci; Jelena M Janjic; John A Pollock Journal: PLoS One Date: 2014-02-28 Impact factor: 3.240