Cristina Calvo1, Paula Gallardo2, Patricia Torija3, Sara Bellón4, Ana Méndez-Echeverría5, Teresa Del Rosal6, Fernando Baquero-Artigao7, Talía Sainz8, María Romero9, María Cabrerizo10. 1. Pediatrics Department, Hospital Severo Ochoa, Leganés, Madrid, Spain; Pediatric and Infectious Diseases, Hospital La Paz, La Paz Research Insititute (IdiPAZ), Madrid, Spain. Electronic address: ccalvorey@ono.com. 2. Pediatrics Department, Hospital Severo Ochoa, Leganés, Madrid, Spain. Electronic address: pau88_gp@hotmail.com. 3. Pediatrics Department, Hospital Severo Ochoa, Leganés, Madrid, Spain. 4. Pediatrics Department, Hospital Severo Ochoa, Leganés, Madrid, Spain. Electronic address: sara.bellon.alonso@gmail.com. 5. Pediatric and Infectious Diseases, Hospital La Paz, La Paz Research Insititute (IdiPAZ), Madrid, Spain. Electronic address: amendezes@yahoo.es. 6. Pediatric and Infectious Diseases, Hospital La Paz, La Paz Research Insititute (IdiPAZ), Madrid, Spain. Electronic address: teredelrosal@yahoo.es. 7. Pediatric and Infectious Diseases, Hospital La Paz, La Paz Research Insititute (IdiPAZ), Madrid, Spain. Electronic address: fbaquero@terra.com. 8. Pediatric and Infectious Diseases, Hospital La Paz, La Paz Research Insititute (IdiPAZ), Madrid, Spain. Electronic address: tsainzcosta@gmail.com. 9. Laboratory of Microbiology, Hospital La Paz, Madrid, Spain. Electronic address: mromero.hulp@salud.madrid.org. 10. Enterovirus Unit, National Centre for Microbiology, Health Institute "Carlos III", Madrid, Spain. Electronic address: mcabrerizo@isciii.es.
Abstract
BACKGROUND: Very little information exists on simultaneous infections by viruses and bacteria in infants with fever without source (FWS). OBJECTIVES: To investigate the incidence of bacterial coinfection in infants up to 3 months of age with neurological viral infection. STUDY DESIGN: Prospective study performed in infants below 90 days of age attending the emergency room of two public hospitals in Spain for FWS. Those who had viral screening performed in CSF, together with blood, CSF and urine cultures were included. Herpes virus, EV and HPeV detection in CSF was performed by PCR. Coinfections between viruses in CSF and serious bacterial infections were described. RESULTS: 119 Infants less than 90 days of age were recruited. Forty-five (38%) had viral infection of the central nervous system, and in 8 of them (17.7%) we found a concurrent bacterial infection: 7 urinary tract infections (UTI) and 1 sepsis. In all cases, the virus identified in CSF was EV. CONCLUSIONS: Bacterial infections were frequent in young infants with viral neurological infections associated to EV. Urinary tract infection was the most common bacterial disease. Copyright Â
BACKGROUND: Very little information exists on simultaneous infections by viruses and bacteria in infants with fever without source (FWS). OBJECTIVES: To investigate the incidence of bacterial coinfection in infants up to 3 months of age with neurological viral infection. STUDY DESIGN: Prospective study performed in infants below 90 days of age attending the emergency room of two public hospitals in Spain for FWS. Those who had viral screening performed in CSF, together with blood, CSF and urine cultures were included. Herpes virus, EV and HPeV detection in CSF was performed by PCR. Coinfections between viruses in CSF and serious bacterial infections were described. RESULTS: 119 Infants less than 90 days of age were recruited. Forty-five (38%) had viral infection of the central nervous system, and in 8 of them (17.7%) we found a concurrent bacterial infection: 7 urinary tract infections (UTI) and 1 sepsis. In all cases, the virus identified in CSF was EV. CONCLUSIONS:Bacterial infections were frequent in young infants with viral neurological infections associated to EV. Urinary tract infection was the most common bacterial disease. Copyright Â
Authors: Anne J Blaschke; E Kent Korgenski; Jacob Wilkes; Angela P Presson; Emily A Thorell; Andrew T Pavia; Elizabeth D Knackstedt; Carolyn Reynolds; Jeff E Schunk; Judy A Daly; Carrie L Byington Journal: Pediatrics Date: 2018-01-17 Impact factor: 7.124