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Literature DB >> 27833010

Naringin promotes fracture healing through stimulation of angiogenesis by regulating the VEGF/VEGFR-2 signaling pathway in osteoporotic rats.

Nan Song¹, Zhihu Zhao², Xinlong Ma³, Xiaolei Sun⁴, Jianxiong Ma⁴, Fengbo Li⁴, Lei Sun⁴, Jianwei Lv⁴.

Abstract

Postmenopausal osteoporosis is characterized by a reduction in the number of sinusoidal and arterial capillaries in the bone marrow and reduced bone perfusion. Thus, osteogenesis and angiogenesis are coupled in the process of osteoporosis formation and fracture healing. Naringin is the main ingredient of the root Rhizoma Drynariae, a traditional Chinese medicine, and it has potential effects on promoting fracture healing. However, whether naringin stimulates angiogenesis in the process of bone healing is unclear. Here, we show that naringin promotes fracture healing through stimulating angiogenesis by regulating the VEGF/VEGFR-2 signaling pathway in osteoporotic rats.

Entities: Chemical Disease Gene Species

Keywords: Angiogenesis; Naringin; VEGF; VEGFR-2

Mesh：

Substances：

Year: 2016 PMID： 27833010 DOI： 10.1016/j.cbi.2016.10.020

Source DB: PubMed Journal: Chem Biol Interact ISSN： 0009-2797 Impact factor: 5.192

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Cited

26 in total

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4. Naringin-inlaid silk fibroin/hydroxyapatite scaffold enhances human umbilical cord-derived mesenchymal stem cell-based bone regeneration.

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Naringin promotes fracture healing through stimulation of angiogenesis by regulating the VEGF/VEGFR-2 signaling pathway in osteoporotic rats.

1. Neohesperidin promotes the osteogenic differentiation of bone mesenchymal stem cells by activating the Wnt/β-catenin signaling pathway.

2. Ameliorative effect of naringin against thiram-induced tibial dyschondroplasia in broiler chicken.

3. PAX8-AS1 knockdown facilitates cell growth and inactivates autophagy in osteoblasts via the miR-1252-5p/GNB1 axis in osteoporosis.

4. Naringin-inlaid silk fibroin/hydroxyapatite scaffold enhances human umbilical cord-derived mesenchymal stem cell-based bone regeneration.

5. Chemical characterization of wound ointment (WO) and its effects on fracture repair: a rabbit model.

6. Biotransformation of Flavonoid Conjugates with Fatty Acids and Evaluations of Their Functionalities.

7. Cornuside I promoted osteogenic differentiation of bone mesenchymal stem cells through PI3K/Akt signaling pathway.

8. Identification of hub genes in rheumatoid arthritis through an integrated bioinformatics approach.

9. Naringin improves random skin flap survival in rats.

10. MiR-708 inhibits MC3T3-E1 cells against H₂O₂-induced apoptosis through targeting PTEN.