| Literature DB >> 27832986 |
Yalei Liu1, Yan Gong2, Chenxue Qu3, Yang Zhang4, Ran You5, Nan Yu6, Guizhi Lu7, Youyuan Huang8, Hong Zhang9, Ying Gao10, Yanming Gao11, Xiaohui Guo12.
Abstract
Inhibitory CD32b receptors on B cells are critical for humoral immunity. The humoral response plays a role in the pathogenesis of Hashimoto's thyroiditis (HT). This study aimed to investigate B cell subset distribution and CD32b expression within these subsets in HT patients. B cell subset distribution and CD32b expression were analyzed in 60 HT patients and 21 healthy donors. Subset distribution and CD32b expression following stimulation with α-Ig and α-CD40 were also assessed. The percentage of double-negative (DN) memory cells was increased in the HT patients, while the expression level of CD32b on DN memory cells was decreased. Redistribution of B cell subsets was detected in response to stimulation with α-Ig. In addition, the expression level of CD32b was reduced following α-CD40 stimulation. These results suggest that abnormal B cell subset distribution and decreased CD32b expression on DN memory cells might be involved in the pathogenesis of HT.Entities:
Keywords: B cell subsets; CD32b; Double-negative memory B cells; Hashimoto's thyroiditis
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Year: 2016 PMID： 27832986 DOI： 10.1016/j.mce.2016.11.004
Source DB: PubMed Journal: Mol Cell Endocrinol ISSN： 0303-7207 Impact factor: 4.102