Literature DB >> 27832914

l-Proline, GABA Synthesis and Gamma Oscillations in Schizophrenia.

David W Volk1, Guillermo Gonzalez-Burgos2, David A Lewis3.   

Abstract

Altered inhibition from parvalbumin-containing GABA neurons is thought to contribute to impaired gamma frequency oscillations and cognitive deficits in schizophrenia. Crabtree and colleagues report that proline dehydrogenase deficits produce excessive cytosolic levels of the GABA-mimetic l-proline which impairs GABA synthesis and gamma oscillations in a manner that mimics schizophrenia. Copyright Â
© 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  22q11; GAD; cognition; parvalbumin; postmortem; prefrontal cortex; proline dehydrogenase

Mesh：

Substances：

Year:  2016        PMID： 27832914      PMCID： PMC5157203          DOI： 10.1016/j.tins.2016.10.009

Source DB:  PubMed          Journal:  Trends Neurosci        ISSN： 0166-2236            Impact factor:   13.837


  10 in total

1.  Cortical deficits of glutamic acid decarboxylase 67 expression in schizophrenia: clinical, protein, and cell type-specific features.

Authors:  Allison A Curley; Dominique Arion; David W Volk; Josephine K Asafu-Adjei; Allan R Sampson; Kenneth N Fish; David A Lewis
Journal:  Am J Psychiatry       Date:  2011-06-01       Impact factor: 18.112

2.  Impairments in frontal cortical gamma synchrony and cognitive control in schizophrenia.

Authors:  R Y Cho; R O Konecky; C S Carter
Journal:  Proc Natl Acad Sci U S A       Date:  2006-12-14       Impact factor: 11.205

3.  Cytosolic Accumulation of L-Proline Disrupts GABA-Ergic Transmission through GAD Blockade.

Authors:  Gregg W Crabtree; Alan J Park; Joshua A Gordon; Joseph A Gogos
Journal:  Cell Rep       Date:  2016-10-04       Impact factor: 9.423

4.  The role of the synthetic enzyme GAD65 in the control of neuronal gamma-aminobutyric acid release.

Authors:  N Tian; C Petersen; S Kash; S Baekkeskov; D Copenhagen; R Nicoll
Journal:  Proc Natl Acad Sci U S A       Date:  1999-10-26       Impact factor: 11.205

5.  Frontal Glutamate and γ-Aminobutyric Acid Levels and Their Associations With Mismatch Negativity and Digit Sequencing Task Performance in Schizophrenia.

Authors:  Laura M Rowland; Ann Summerfelt; S Andrea Wijtenburg; Xiaoming Du; Joshua J Chiappelli; Nithin Krishna; Jeffrey West; Florian Muellerklein; Peter Kochunov; L Elliot Hong
Journal:  JAMA Psychiatry       Date:  2016-02       Impact factor: 21.596

Review 6.  Alterations in cortical network oscillations and parvalbumin neurons in schizophrenia.

Authors:  Guillermo Gonzalez-Burgos; Raymond Y Cho; David A Lewis
Journal:  Biol Psychiatry       Date:  2015-03-17       Impact factor: 13.382

7.  Lower glutamic acid decarboxylase 65-kDa isoform messenger RNA and protein levels in the prefrontal cortex in schizoaffective disorder but not schizophrenia.

Authors:  Jill R Glausier; Sohei Kimoto; Kenneth N Fish; David A Lewis
Journal:  Biol Psychiatry       Date:  2014-05-29       Impact factor: 13.382

8.  Parvalbumin neurons and gamma rhythms enhance cortical circuit performance.

Authors:  Vikaas S Sohal; Feng Zhang; Ofer Yizhar; Karl Deisseroth
Journal:  Nature       Date:  2009-04-26       Impact factor: 49.962

9.  Deficits in transcriptional regulators of cortical parvalbumin neurons in schizophrenia.

Authors:  David W Volk; Takurou Matsubara; Siyu Li; Elizabeth J Sengupta; Danko Georgiev; Yoshio Minabe; Allan Sampson; Takanori Hashimoto; David A Lewis
Journal:  Am J Psychiatry       Date:  2012-10       Impact factor: 18.112

10.  GAD67 deficiency in parvalbumin interneurons produces deficits in inhibitory transmission and network disinhibition in mouse prefrontal cortex.

Authors:  Matthew S Lazarus; Keerthi Krishnan; Z Josh Huang
Journal:  Cereb Cortex       Date:  2013-11-24       Impact factor: 5.357
  10 in total
  1 in total

1.  Metabolomics approach revealed robust changes in amino acid and biogenic amine signatures in patients with schizophrenia in the early course of the disease.

Authors:  Madis Parksepp; Liisa Leppik; Kadri Koch; Kärt Uppin; Raul Kangro; Liina Haring; Eero Vasar; Mihkel Zilmer
Journal:  Sci Rep       Date:  2020-08-19       Impact factor: 4.379
  1 in total

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