Literature DB >> 27832495

Adhesion GPCRs as Modulators of Immune Cell Function.

Jörg Hamann1, Cheng-Chih Hsiao2, Chang Sup Lee3, Kodi S Ravichandran3, Hsi-Hsien Lin4,5.   

Abstract

Immune cells express several adhesion G protein-coupled receptors (aGPCRs), including the ADGRE subfamily members EMR1 (F4/80, ADGRE1), EMR2 (ADGRE2), EMR3 (ADGRE3), EMR4 (FIRE, ADGRE4), and CD97 (ADGRE5), the ADGRB subfamily member BAI1 (ADGRB1), and the ADGRG subfamily members GPR56 (ADGRG1), GPR97 (Pb99, ADGRG3), and GPR114 (ADGRG5). Expression of these molecules in hematopoietic stem and progenitor cells, monocytes/macrophages (Mφs), dendritic cells, granulocytes, and lymphocytes depends on lineage diversification and maturation, making them suitable markers for individual leukocyte subsets (e.g., F4/80 on mouse Mφs). Recent studies revealed intriguing activities of aGPCRs in tolerance induction (EMR1), granulopoiesis (CD97), engulfment of apoptotic cells and bacteria (BAI1), hematopoietic stem cell formation (GPR56), and control of cytotoxicity (GPR56). Here, we review these findings and discuss their biological and translational implications.

Entities:  

Keywords:  Adhesion GPCRs; Granulocytes; Immunity; Macrophages; Phagocytosis; T cells

Mesh：

Substances：

Year:  2016        PMID： 27832495     DOI： 10.1007/978-3-319-41523-9_15

Source DB:  PubMed          Journal:  Handb Exp Pharmacol        ISSN： 0171-2004


  15 in total

1.  Epigenetic profiling linked to multisystem inflammatory syndrome in children (MIS-C): A multicenter, retrospective study.

Authors:  Veronica Davalos; Carlos A García-Prieto; Gerardo Ferrer; Sergio Aguilera-Albesa; Juan Valencia-Ramos; Agustí Rodríguez-Palmero; Montserrat Ruiz; Laura Planas-Serra; Iolanda Jordan; Iosune Alegría; Patricia Flores-Pérez; Verónica Cantarín; Victoria Fumadó; Maria Teresa Viadero; Carlos Rodrigo; Maria Méndez-Hernández; Eduardo López-Granados; Roger Colobran; Jacques G Rivière; Pere Soler-Palacín; Aurora Pujol; Manel Esteller
Journal:  EClinicalMedicine       Date:  2022-06-25

Review 2.  Adhesion G Protein-Coupled Receptors as Drug Targets.

Authors:  Ryan H Purcell; Randy A Hall
Journal:  Annu Rev Pharmacol Toxicol       Date:  2017-10-02       Impact factor: 13.820

Review 3.  Macrophage Clearance of Apoptotic Cells: A Critical Assessment.

Authors:  Siamon Gordon; Annette Plüddemann
Journal:  Front Immunol       Date:  2018-01-30       Impact factor: 7.561

4.  Genome-wide gene expression analysis of amphioxus (Branchiostoma belcheri) following lipopolysaccharide challenge using strand-specific RNA-seq.

Authors:  Qi-Lin Zhang; Qian-Hua Zhu; Zheng-Qing Xie; Bin Xu; Xiu-Qiang Wang; Jun-Yuan Chen
Journal:  RNA Biol       Date:  2017-09-21       Impact factor: 4.652

5.  The Adhesion G Protein-Coupled Receptor GPR97/ADGRG3 Is Expressed in Human Granulocytes and Triggers Antimicrobial Effector Functions.

Authors:  Cheng-Chih Hsiao; Tai-Ying Chu; Chia-Jung Wu; Maartje van den Biggelaar; Caroline Pabst; Josée Hébert; Taco W Kuijpers; Brendon P Scicluna; Kuan-Yu I; Tse-Ching Chen; Ines Liebscher; Jörg Hamann; Hsi-Hsien Lin
Journal:  Front Immunol       Date:  2018-12-03       Impact factor: 7.561

6.  Macrophages Do Not Express the Phagocytic Receptor BAI1/ADGRB1.

Authors:  Cheng-Chih Hsiao; Marlijn van der Poel; Tjakko J van Ham; Jörg Hamann
Journal:  Front Immunol       Date:  2019-05-03       Impact factor: 7.561

Review 7.  Understanding the Role of the BAI Subfamily of Adhesion G Protein-Coupled Receptors (GPCRs) in Pathological and Physiological Conditions.

Authors:  Sun Young Moon; Seong-Ah Shin; Yong-Seok Oh; Hyun Ho Park; Chang Sup Lee
Journal:  Genes (Basel)       Date:  2018-11-30       Impact factor: 4.096

8.  Genetic basis of functional variability in adhesion G protein-coupled receptors.

Authors:  Alexander Bernd Knierim; Juliane Röthe; Mehmet Volkan Çakir; Vera Lede; Caroline Wilde; Ines Liebscher; Doreen Thor; Torsten Schöneberg
Journal:  Sci Rep       Date:  2019-07-30       Impact factor: 4.379

9.  ADGRL4/ELTD1 Expression in Breast Cancer Cells Induces Vascular Normalization and Immune Suppression.

Authors:  Helen Sheldon; Esther Bridges; Ildefonso Silva; Massimo Masiero; David M Favara; Dian Wang; Russell Leek; Cameron Snell; Ioannis Roxanis; Mira Kreuzer; Uzi Gileadi; Francesca M Buffa; Alison Banham; Adrian L Harris
Journal:  Mol Cancer Res       Date:  2021-08-04       Impact factor: 5.852

10.  The repertoire of Adhesion G protein-coupled receptors in adipocytes and their functional relevance.

Authors:  Tomáš Suchý; Christian Zieschang; Ines Liebscher; Doreen Thor; Yulia Popkova; Isabell Kaczmarek; Juliane Weiner; Aenne-Dorothea Liebing; Mehmet Volkan Çakir; Kathrin Landgraf; Martin Gericke; John Andrew Pospisilik; Antje Körner; John T Heiker; Dirk Dannenberger; Jürgen Schiller; Torsten Schöneberg
Journal:  Int J Obes (Lond)       Date:  2020-03-19       Impact factor: 5.095
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