| Literature DB >> 27830840 |
Grzegorz Framski1, Dariusz Wawrzyniak1, Zofia Jahnz-Wechmann1, Agnieszka Szymanska-Michalak1, Adam Kraszewski1, Jan Barciszewski1, Jerzy Boryski1, Jacek Stawinski1.
Abstract
Several ribonucleoside analogues with modifications in the nucleobase and sugar moiety have been screened for anti-glioma activity in the T98G glioma cell line using cervical (HeLa) cell line as reference human malignant cells, and lung fibroblast (MCR-5) cell line as non-cancerous reference cells. Among the investigated compounds, ribonucleosides containing 6-chloropurine (3), 7-guanine (5) and a pyrrolopyrimidine (18) as nucleobases, show promising anti-glioma activity with good selectivity indices, and can be considered as lead structures for further anti-cancer studies.Entities:
Mesh：
Substances：
Year: 2016 PMID： 27830840 DOI： 10.18388/abp.2016_1338
Source DB: PubMed Journal: Acta Biochim Pol ISSN： 0001-527X Impact factor: 2.149