Literature DB >> 27830674

[Protein complexes coordinating mRNA export from the nucleus into the cytoplasm].

M M Kurshakova1,2, S G Georgieva1, D V Kopytova1.   

Abstract

The molecular mechanisms that coordinate transcription, processing, mRNP assembly, and mRNA export from the nucleus through nuclear pores into the cytoplasm have been the focus of intense research in recent years. Data demonstrating a tight association between the processes involved in gene expression are considered. The main protein complexes that play a role in mRNA export are described. The complexes are recruited to mRNA at steps preceding the mRNA export. The functions that the complexes perform at particular steps of gene expression are analyzed, and protein complexes responsible for quality control of mRNP discussed.

Keywords:  NPC; THO; TREX-2; mRNA; mRNA export; mRNP

Mesh:

Substances:

Year:  2016        PMID: 27830674     DOI: 10.7868/S0026898416050098

Source DB:  PubMed          Journal:  Mol Biol (Mosk)        ISSN: 0026-8984


  2 in total

1.  Mud2 functions in transcription by recruiting the Prp19 and TREX complexes to transcribed genes.

Authors:  Rashmi Minocha; Varvara Popova; Daria Kopytova; Danny Misiak; Stefan Hüttelmaier; Sofia Georgieva; Katja Sträßer
Journal:  Nucleic Acids Res       Date:  2018-10-12       Impact factor: 16.971

2.  Reduction of mRNA export unmasks different tissue sensitivities to low mRNA levels during Caenorhabditis elegans development.

Authors:  Angelina Zheleva; Eva Gómez-Orte; Beatriz Sáenz-Narciso; Begoña Ezcurra; Henok Kassahun; María de Toro; Antonio Miranda-Vizuete; Ralf Schnabel; Hilde Nilsen; Juan Cabello
Journal:  PLoS Genet       Date:  2019-09-16       Impact factor: 5.917

  2 in total

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