Literature DB >> 27830549

Successful Engraftment of Human Hepatocytes in uPA-SCID and FRG® KO Mice.

Lander Foquet1, Elizabeth M Wilson2, Lieven Verhoye1, Markus Grompe2,3, Geert Leroux-Roels1, John Bial2, Philip Meuleman4.   

Abstract

Mice with humanized chimeric liver are promising in vivo tools to evaluate the efficacy of novel compounds or vaccine induced antibodies directed against pathogens that infect the human liver. In addition they can be used to study the human-type metabolism of medicinal compounds and hepatotoxicity.

Entities:  

Keywords:  Humanized mouse model; In vivo; Liver; Malaria; Metabolism; Plasmodium falciparum; Viral hepatitis

Mesh：

Substances：

Year:  2017        PMID： 27830549     DOI： 10.1007/978-1-4939-6506-9_8

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  9 in total

1.  Efficacy of hepatitis B virus ribonuclease H inhibitors, a new class of replication antagonists, in FRG human liver chimeric mice.

Authors:  Kelly R Long; Elena Lomonosova; Qilan Li; Nathan L Ponzar; Juan A Villa; Erin Touchette; Stephen Rapp; R Matt Liley; Ryan P Murelli; Alexandre Grigoryan; R Mark Buller; Lisa Wilson; John Bial; John E Sagartz; John E Tavis
Journal:  Antiviral Res       Date:  2017-11-10       Impact factor: 5.970

2.  Human Hepatocyte Transduction with Adeno-Associated Virus Vector.

Authors:  Zhenwei Song; Wenwei Shao; Liujiang Song; Xieolei Pei; Chengwen Li
Journal:  Methods Mol Biol       Date:  2022

3.  A Plasmodium berghei sporozoite-based vaccination platform against human malaria.

Authors:  António M Mendes; Marta Machado; Nataniel Gonçalves-Rosa; Isaie J Reuling; Lander Foquet; Cláudia Marques; Ahmed M Salman; Annie S P Yang; Kara A Moser; Ankit Dwivedi; Cornelus C Hermsen; Belén Jiménez-Díaz; Sara Viera; Jorge M Santos; Inês Albuquerque; Sangeeta N Bhatia; John Bial; Iñigo Angulo-Barturen; Joana C Silva; Geert Leroux-Roels; Chris J Janse; Shahid M Khan; Maria M Mota; Robert W Sauerwein; Miguel Prudêncio
Journal:  NPJ Vaccines       Date:  2018-08-24       Impact factor: 7.344

Review 4.  Animal Models for Hepatitis E virus.

Authors:  Laura Corneillie; Dominic H Banda; Philip Meuleman
Journal:  Viruses       Date:  2019-06-18       Impact factor: 5.048

5.  Molecular characterization of precise in vivo targeted gene integration in human cells using AAVHSC15.

Authors:  Huei-Mei Chen; Rachel Resendes; Azita Ghodssi; Danielle Sookiasian; Michael Tian; Serena Dollive; Laura Adamson-Small; Nancy Avila; Cagdas Tazearslan; John F Thompson; Jeff L Ellsworth; Omar Francone; Albert Seymour; Jason B Wright
Journal:  PLoS One       Date:  2020-05-26       Impact factor: 3.240

6.  Sexual Dimorphism in Hepatocyte Xenograft Models.

Authors:  Gulce Sari; Gertine W van Oord; Martijn D B van de Garde; Jolanda J C Voermans; Andre Boonstra; Thomas Vanwolleghem
Journal:  Cell Transplant       Date:  2021 Jan-Dec       Impact factor: 4.064

7.  Human antibodies against noncircumsporozoite proteins block Plasmodium falciparum parasite development in hepatocytes.

Authors:  Amanda Fabra-García; Annie Sp Yang; Marije C Behet; Zen Yap; Youri van Waardenburg; Swarnendu Kaviraj; Kjerstin Lanke; Geert-Jan van Gemert; Matthijs M Jore; Teun Bousema; Robert W Sauerwein
Journal:  JCI Insight       Date:  2022-03-22

8.  Proteomic analysis of hepatic effects of phenobarbital in mice with humanized liver.

Authors:  Heike Sprenger; Josef Daniel Rasinger; Helen Hammer; Wael Naboulsi; Elke Zabinsky; Hannes Planatscher; Michael Schwarz; Oliver Poetz; Albert Braeuning
Journal:  Arch Toxicol       Date:  2022-07-26       Impact factor: 6.168

9.  Insights From Liver-Humanized Mice on Cholesterol Lipoprotein Metabolism and LXR-Agonist Pharmacodynamics in Humans.

Authors:  Mirko E Minniti; Matteo Pedrelli; Lise-Lotte Vedin; Anne-Sophie Delbès; Raphaël G P Denis; Katariina Öörni; Claudia Sala; Chiara Pirazzini; Divya Thiagarajan; Harri J Nurmi; Markus Grompe; Kevin Mills; Paolo Garagnani; Ewa C S Ellis; Stephen C Strom; Serge H Luquet; Elizabeth M Wilson; John Bial; Knut R Steffensen; Paolo Parini
Journal:  Hepatology       Date:  2020-03-23       Impact factor: 17.425
  9 in total

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