| Literature DB >> 27830542 |
Zahida Khan1,2, Stephen C Strom3.
Abstract
Orthotopic liver transplantation remains the only proven cure for end-stage liver failure. Despite significant advances in the field, the clinical demand for donor organs far outweighs the supply. Hepatocyte transplantation has been proposed as an alternative approach to whole liver transplant in select diseases. Several international centers have reported experimental trials of human hepatocyte transplantation in acute liver failure and liver-based metabolic disorders. This chapter provides an introduction to hepatocyte transplantation from both a technical and clinical perspective. We will also focus on the special needs of pediatric patients, since historically the majority of clinical hepatocyte transplants have involved infants and children.Entities:
Keywords: Cell therapy; Gene therapy; Hepatocyte transplant; Human hepatocytes; Metabolic liver disease; Pediatric liver disease; Regenerative medicine
Mesh：
Year: 2017 PMID： 27830542 PMCID： PMC5125821 DOI： 10.1007/978-1-4939-6506-9_1
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745