Bei Lv1, Xin Cheng2, Jackson Gao3, Hong Zhao4, Liping Chen1, Liwei Wang5, Shaoping Huang1, Zhenyu Fan1, Renfang Zhang1, Yinzhong Shen1, Lei Li1, Baochi Liu1, Tangkai Qi1, Jing Wang6, Jilin Cheng7. 1. Department of Gastroenterology, Shanghai Public Health Clinical Center, Fudan University Shanghai, China. 2. Shanghai Jiaotong University Medical School Shanghai, China. 3. Albert Einstein College of Medicine Bronx, New York, USA. 4. Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University Wenzhou, Zhejiang, China. 5. Department of Gastroenterology, The First Affiliated Hospital of Jilin University Jilin, China. 6. Department of Hepatology, Tianjing Second People's Hospital Tianjing, China. 7. Department of Gastroenterology, Shanghai Public Health Clinical Center, Fudan UniversityShanghai, China; Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou, Zhejiang, China.
Abstract
OBJECTIVE: This study aimed to determine whether the human immunodeficiency virus (HIV) exists in giant idiopathic esophageal ulcers in the patients with acquired immune deficiency syndrome (AIDS). METHODS: 16 AIDS patients with a primary complaint of epigastric discomfort were examined by gastroscopy. Multiple and giant esophageal ulcers were biopsied and analyzed with pathology staining and reverse transcription-polymerase chain reaction (RT-PCR) to determine the potential pathogenic microorganisms, including HIV, cytomegalovirus (CMV) and herpes simplex viruses (HSV). RESULTS: HIV was detected in ulcer samples from 12 out of these 16 patients. Ulcers in 2 patients were infected with CMV and ulcers in another 2 patients were found HSV positive. No obvious cancerous pathological changes were found in these multiple giant esophageal ulcer specimens. CONCLUSION: HIV may be one of the major causative agents of multiple benign giant esophageal ulcers in AIDS patients.
OBJECTIVE: This study aimed to determine whether the human immunodeficiency virus (HIV) exists in giant idiopathic esophageal ulcers in the patients with acquired immune deficiency syndrome (AIDS). METHODS: 16 AIDSpatients with a primary complaint of epigastric discomfort were examined by gastroscopy. Multiple and giant esophageal ulcers were biopsied and analyzed with pathology staining and reverse transcription-polymerase chain reaction (RT-PCR) to determine the potential pathogenic microorganisms, including HIV, cytomegalovirus (CMV) and herpes simplex viruses (HSV). RESULTS:HIV was detected in ulcer samples from 12 out of these 16 patients. Ulcers in 2 patients were infected with CMV and ulcers in another 2 patients were found HSV positive. No obvious cancerous pathological changes were found in these multiple giant esophageal ulcer specimens. CONCLUSION:HIV may be one of the major causative agents of multiple benign giant esophageal ulcers in AIDSpatients.
Authors: Jùnia Maria Netto Victória; André Luiz Sena Guimarães; Luciano Marques da Silva; Evanguedes Kalapothakis; Ricardo Santiago Gomez Journal: Microbiol Res Date: 2005 Impact factor: 5.415