Biaoxue Rong1, Xiguang Cai2, Hua Liu2, Tian Fu3, Wenlong Gao4, Chongchong Zhao5, Yurong Lin6. 1. Department of Respiratory Medicine, First Affiliated Hospital, Xi'an Medical University Xi'an, China. 2. Department of Respiratory Medicine, Gansu Provincial Hospital Lanzhou, China. 3. Department of Respiratory Medicine, Affiliated Hospital of Jining Medical University Jining, China. 4. Department of Statistics and Epidemiology, Medical College, Lanzhou University Lanzhou, China. 5. Department of Cancer Care, Lanzhou University Second Hospital Lanzhou, China. 6. Department of Respiratory Medicine, Xi'an North Hospital Xian, China.
Abstract
BACKGROUND: The purpose of this work is to explore the correlation between Hsp90-beta level in broncheoalveolar lavage fluid (BALF) and lung cancer. METHODS: Hsp90-beta level was measured by immunohistochemistry and enzyme-linked immunosorbent assay. Sensitivity and specificity of Hsp90-beta were calculated by receiver operator characteristic curve. RESULTS: BALF in patients with lung cancer showed a higher expression of Hsp90-beta than those with benign lung disease (P<0.05). Elevated Hsp90-beta was closely related to lymphatic invasion and advanced stage of patients with lung cancer (P<0.05). The sensitivity of BALF Hsp90-beta for discerning lung cancer from patients with benign disease was 82.56% and specificity was 97.56%. CONCLUSION: Increased BALF Hsp90-beta correlates with lymphatic invasion and advanced stage of patients with lung cancer, suggesting it could be a diagnostic indicator for patients with lung cancer.
BACKGROUND: The purpose of this work is to explore the correlation between Hsp90-beta level in broncheoalveolar lavage fluid (BALF) and lung cancer. METHODS:Hsp90-beta level was measured by immunohistochemistry and enzyme-linked immunosorbent assay. Sensitivity and specificity of Hsp90-beta were calculated by receiver operator characteristic curve. RESULTS: BALF in patients with lung cancer showed a higher expression of Hsp90-beta than those with benign lung disease (P<0.05). Elevated Hsp90-beta was closely related to lymphatic invasion and advanced stage of patients with lung cancer (P<0.05). The sensitivity of BALF Hsp90-beta for discerning lung cancer from patients with benign disease was 82.56% and specificity was 97.56%. CONCLUSION: Increased BALF Hsp90-beta correlates with lymphatic invasion and advanced stage of patients with lung cancer, suggesting it could be a diagnostic indicator for patients with lung cancer.
Authors: Rong Biaoxue; Yang Shuanying; Li Wei; Ming Zongjuan; Cai Xiguang; Zhang Qiuhong Journal: Expert Rev Mol Diagn Date: 2014-10-10 Impact factor: 5.225
Authors: Coşkun Güzel; Caroline B van den Berg; Johannes J Duvekot; Christoph Stingl; Thierry P P van den Bosch; Marcel van der Weiden; Eric A P Steegers; Regine P M Steegers-Theunissen; Theo M Luider Journal: Proteomics Clin Appl Date: 2018-11-26 Impact factor: 3.494