Literature DB >> 27829328

Use of Oritavancin (Novel New Lipoglycopeptide) in the Treatment of Prosthetic Joint Infections (PJI): A Possible Alternative Novel Approach to a Difficult Problem.

Suresh J Antony1, Leigh G Cooper2.   

Abstract

Prosthetic joint infections (PJI) result in significant morbidity, mortality and cost to patients and the health system. Traditional treatment involves a twostaged revision and occasionally a single staged revision along with intravenous antibiotics (IV) and or oral antibiotics for several weeks to months. The use of a single staged revision along with an antibiotic which has a prolonged half life and is bactericidal would be ideal. We present 2 patients who were treated successfully with a single stage revision/antibiotic spacer and a new novel long acting lipoglycopeptide called oritavancin. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Entities:  

Keywords:  Morbidity; Oritavancin; intravenous; lipoglycopeptide; prosthetic joint

Mesh:

Substances:

Year:  2017        PMID: 27829328     DOI: 10.2174/1871526517666161108130148

Source DB:  PubMed          Journal:  Infect Disord Drug Targets        ISSN: 1871-5265


  4 in total

1.  Developments in Glycopeptide Antibiotics.

Authors:  Mark A T Blaskovich; Karl A Hansford; Mark S Butler; ZhiGuang Jia; Alan E Mark; Matthew A Cooper
Journal:  ACS Infect Dis       Date:  2018-02-19       Impact factor: 5.084

2.  A Real-world Patient Registry for Oritavancin Demonstrates Efficacy and Safety Consistent With the Phase 3 SOLO Program.

Authors:  Mark Redell; Greg Moeck; Christopher Lucasti; Stephanie Durso; Cynthia Kennedy; Karen Fusaro; Jeff Loutit; Michael Dudley
Journal:  Open Forum Infect Dis       Date:  2018-03-19       Impact factor: 3.835

3.  The CHROME Study, a Real-world Experience of Single- and Multiple-Dose Oritavancin for Treatment of Gram-Positive Infections.

Authors:  Mark Redell; Miguel Sierra-Hoffman; Maha Assi; Markian Bochan; David Chansolme; Anurag Gandhi; Kathleen Sheridan; Ivan Soosaipillai; Thomas Walsh; Jill Massey
Journal:  Open Forum Infect Dis       Date:  2019-11-04       Impact factor: 3.835

4.  Efficacy and safety of novel glycopeptides versus vancomycin for the treatment of gram-positive bacterial infections including methicillin resistant Staphylococcus aureus: A systematic review and meta-analysis.

Authors:  Wissal Jame; Bilgen Basgut; Abdikarim Abdi
Journal:  PLoS One       Date:  2021-11-29       Impact factor: 3.240

  4 in total

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