Biao Xu1, Xiaobo Yang2, Chunyao Wang3, Wei Jiang4, Li Weng5, Xiaoyun Hu6, Jinmin Peng7, Bin Du8. 1. Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Shuai Fu Yuan, Beijing 100730, PR China. Electronic address: xubiao0302@163.com. 2. Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Shuai Fu Yuan, Beijing 100730, PR China. Electronic address: want.tofly@aliyun.com. 3. Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Shuai Fu Yuan, Beijing 100730, PR China. Electronic address: wangchunyao@pumch.cn. 4. Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Shuai Fu Yuan, Beijing 100730, PR China. Electronic address: edwardjw@163.com. 5. Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Shuai Fu Yuan, Beijing 100730, PR China. Electronic address: wengli@pumch.cn. 6. Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Shuai Fu Yuan, Beijing 100730, PR China. Electronic address: emi75@sina.com. 7. Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Shuai Fu Yuan, Beijing 100730, PR China. Electronic address: pjm731@hotmail.com. 8. Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Shuai Fu Yuan, Beijing 100730, PR China. Electronic address: dubin98@gmail.com.
Abstract
PURPOSE: To evaluate whether the changes of central venous oxygen saturation (Scvo2) after fluid challenge can define fluid responsiveness in patients with septic shock. METHODS: In this prospective observational study, septic shock patients with invasive cardiac output monitoring requiring fluid challenge were included. Cardiac index (CI) and Scvo2 were measured before and after fluid challenges. The changes of CI (ΔCI) and the changes of Scvo2 (ΔScvo2) were calculated and analyzed using Pearson correlation. Receiver operating characteristics curve (ROC) analysis was used to classify fluid responders and nonresponders. Area under ROC was calculated. RESULTS: Forty patients were included and 18 patients (45%) were fluid responders. In the responders, CI increased from 3.4±1.1 to 4.4±1.0 L min-1 m-2 and Scvo2 from 69.6%±9.8% to 77.1%±8.9% (both P<.001) after fluid challenge. In the nonresponders, neither CI nor Scvo2 changed (4.1±1.3 vs 4.1±1.3 L min-1 m-2, 71.0%±13.8% vs 70.6%±14.1%, both P>.05). The correlation between ΔScvo2 and ΔCI was significant (r=0.702, P<.001). The area under ROC of ΔScvo2 to define fluid responsiveness was 0.88 (95% confidence interval [95% CI], 0.76-0.99). A ΔScvo2 threshold value of 5.0% discriminated responders from nonresponders with sensitivity of 0.78 (95% CI, 0.52-0.93) and specificity of 0.95 (95% CI, 0.75-1.00). CONCLUSIONS: The changes of Scvo2 correlate with the changes of CI, and the changes of Scvo2 define fluid responsiveness in patients with septic shock.
PURPOSE: To evaluate whether the changes of central venous oxygen saturation (Scvo2) after fluid challenge can define fluid responsiveness in patients with septic shock. METHODS: In this prospective observational study, septic shockpatients with invasive cardiac output monitoring requiring fluid challenge were included. Cardiac index (CI) and Scvo2 were measured before and after fluid challenges. The changes of CI (ΔCI) and the changes of Scvo2 (ΔScvo2) were calculated and analyzed using Pearson correlation. Receiver operating characteristics curve (ROC) analysis was used to classify fluid responders and nonresponders. Area under ROC was calculated. RESULTS: Forty patients were included and 18 patients (45%) were fluid responders. In the responders, CI increased from 3.4±1.1 to 4.4±1.0 L min-1 m-2 and Scvo2 from 69.6%±9.8% to 77.1%±8.9% (both P<.001) after fluid challenge. In the nonresponders, neither CI nor Scvo2 changed (4.1±1.3 vs 4.1±1.3 L min-1 m-2, 71.0%±13.8% vs 70.6%±14.1%, both P>.05). The correlation between ΔScvo2 and ΔCI was significant (r=0.702, P<.001). The area under ROC of ΔScvo2 to define fluid responsiveness was 0.88 (95% confidence interval [95% CI], 0.76-0.99). A ΔScvo2 threshold value of 5.0% discriminated responders from nonresponders with sensitivity of 0.78 (95% CI, 0.52-0.93) and specificity of 0.95 (95% CI, 0.75-1.00). CONCLUSIONS: The changes of Scvo2 correlate with the changes of CI, and the changes of Scvo2 define fluid responsiveness in patients with septic shock.
Authors: Armin A Quispe-Cornejo; Ana L Alves da Cunha; Hassane Njimi; Wasineenart Mongkolpun; Ana L Valle-Martins; Mónica Arébalo-López; Jacques Creteur; Jean-Louis Vincent Journal: Crit Care Date: 2022-10-23 Impact factor: 19.334