Literature DB >> 27829135

Macrophage Metabolism Shapes Angiogenesis in Tumors.

Alberto Mantovani1, Massimo Locati2.   

Abstract

In this issue, Wenes et al. (2016) show that REDD1, an mTOR inhibitor induced by hypoxia, enhances glycolysis in tumor-associated macrophages (TAMs). Metabolic competition for glucose between TAMs and endothelial cells leads to an abnormal, leaky vascular network. Targeting REDD1 normalizes glycolysis in TAMs, stabilizes the vascular network, and inhibits metastasis.
Copyright © 2016 Elsevier Inc. All rights reserved.

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Year:  2016        PMID： 27829135     DOI： 10.1016/j.cmet.2016.10.016

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  10 in total

1.  An epigenetic modifier triggers therapeutic immune responses against breast cancer.

Authors:  Lorenzo Galluzzi; Guido Kroemer
Journal:  Oncoimmunology       Date:  2017-04-05       Impact factor: 8.110

2.  Modulating the Tumor Microenvironment via Oncolytic Viruses and CSF-1R Inhibition Synergistically Enhances Anti-PD-1 Immunotherapy.

Authors:  Gang Shi; Qianmei Yang; Yujing Zhang; Qingyuan Jiang; Yi Lin; Shenshen Yang; Huiling Wang; Lin Cheng; Xin Zhang; Yimin Li; Qingnan Wang; Yi Liu; Qin Wang; Hantao Zhang; Xiaolan Su; Lei Dai; Lei Liu; Shuang Zhang; Jia Li; Zhi Li; Yang Yang; Dechao Yu; Yuquan Wei; Hongxin Deng
Journal:  Mol Ther       Date:  2018-11-17       Impact factor: 11.454

3.  Long-chain omega-3 polyunsaturated fatty acids decrease mammary tumor growth, multiorgan metastasis and enhance survival.

Authors:  Saraswoti Khadge; Geoffrey M Thiele; John Graham Sharp; Timothy R McGuire; Lynell W Klassen; Paul N Black; Concetta C DiRusso; Leah Cook; James E Talmadge
Journal:  Clin Exp Metastasis       Date:  2018-10-16       Impact factor: 5.150

4.  Enhanced Lipid Accumulation and Metabolism Are Required for the Differentiation and Activation of Tumor-Associated Macrophages.

Authors:  Pan Su; Qiang Wang; Enguang Bi; Xingzhe Ma; Lintao Liu; Maojie Yang; Jianfei Qian; Qing Yi
Journal:  Cancer Res       Date:  2020-02-03       Impact factor: 12.701

5.  Hypoxia decreases macrophage glycolysis and M1 percentage by targeting microRNA-30c and mTOR in human gastric cancer.

Authors:  Yun Zhihua; Tan Yulin; Wang Yibo; Ding Wei; Chu Yin; Xu Jiahao; Jiang Runqiu; Xu Xuezhong
Journal:  Cancer Sci       Date:  2019-07-12       Impact factor: 6.716

6.  Retinoid X receptor agonist LG100268 modulates the immune microenvironment in preclinical breast cancer models.

Authors:  Ana S Leal; Kayla Zydeck; Sarah Carapellucci; Lyndsey A Reich; Di Zhang; Jessica A Moerland; Michael B Sporn; Karen T Liby
Journal:  NPJ Breast Cancer       Date:  2019-11-01

Review 7.  Macrophages and Metabolic Reprograming in the Tumor Microenvironment.

Authors:  Jin Liu; Mingwei Gao; Zhou Yang; Yidan Zhao; Kun Guo; Binwen Sun; Zhenming Gao; Liming Wang
Journal:  Front Oncol       Date:  2022-02-15       Impact factor: 6.244

Review 8.  Nutritional Sensor REDD1 in Cancer and Inflammation: Friend or Foe?

Authors:  Ekaterina M Zhidkova; Evgeniya S Lylova; Diana D Grigoreva; Kirill I Kirsanov; Alena V Osipova; Evgeny P Kulikov; Sergey A Mertsalov; Gennady A Belitsky; Irina Budunova; Marianna G Yakubovskaya; Ekaterina A Lesovaya
Journal:  Int J Mol Sci       Date:  2022-08-26       Impact factor: 6.208

Review 9.  Immunosuppression in tumor immune microenvironment and its optimization from CAR-T cell therapy.

Authors:  Zaoqu Liu; Zhaokai Zhou; Qin Dang; Hui Xu; Jinxiang Lv; Huanyun Li; Xinwei Han
Journal:  Theranostics       Date:  2022-08-29       Impact factor: 11.600

10.  Prognostic Value of Macrophage-Associated Long Non-Coding RNA Expression for Hepatocellular Carcinoma.

Authors:  Guan-Yu Chen; Duo Wang
Journal:  Cancer Manag Res       Date:  2022-01-14       Impact factor: 3.989
  10 in total

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