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Literature DB >> 27829134

Metabolic Signaling Drives IFN-γ.

Abstract

IFN-γ is a critical inflammatory cytokine that is closely regulated to cellular metabolic status and requires high rates of glycolysis. It has now been shown that a key mechanism to link these pathways is through maintenance of acetyl-CoA and epigenetic regulation of the IFNG locus.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2016 PMID： 27829134 PMCID： PMC5292925 DOI： 10.1016/j.cmet.2016.10.018

Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287

9 in total

Review 1. Metabolic control of epigenetics in cancer.

Authors: Adam Kinnaird; Steven Zhao; Kathryn E Wellen; Evangelos D Michelakis
Journal: Nat Rev Cancer Date: 2016-09-16 Impact factor: 60.716

2. LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.

Authors: Almut Brand; Katrin Singer; Gudrun E Koehl; Marlene Kolitzus; Gabriele Schoenhammer; Annette Thiel; Carina Matos; Christina Bruss; Sebastian Klobuch; Katrin Peter; Michael Kastenberger; Christian Bogdan; Ulrike Schleicher; Andreas Mackensen; Evelyn Ullrich; Stefan Fichtner-Feigl; Rebecca Kesselring; Matthias Mack; Uwe Ritter; Maximilian Schmid; Christian Blank; Katja Dettmer; Peter J Oefner; Petra Hoffmann; Stefan Walenta; Edward K Geissler; Jacques Pouyssegur; Andreas Villunger; André Steven; Barbara Seliger; Stephan Schreml; Sebastian Haferkamp; Elisabeth Kohl; Sigrid Karrer; Mark Berneburg; Wolfgang Herr; Wolfgang Mueller-Klieser; Kathrin Renner; Marina Kreutz
Journal: Cell Metab Date: 2016-09-15 Impact factor: 27.287

3. Posttranscriptional control of T cell effector function by aerobic glycolysis.

Authors: Chih-Hao Chang; Jonathan D Curtis; Leonard B Maggi; Brandon Faubert; Alejandro V Villarino; David O'Sullivan; Stanley Ching-Cheng Huang; Gerritje J W van der Windt; Julianna Blagih; Jing Qiu; Jason D Weber; Edward J Pearce; Russell G Jones; Erika L Pearce
Journal: Cell Date: 2013-06-06 Impact factor: 41.582

4. Differentiation-dependent functional and epigenetic landscapes for cytokine genes in virus-specific CD8+ T cells.

Authors: Alice E Denton; Brendan E Russ; Peter C Doherty; Sudha Rao; Stephen J Turner
Journal: Proc Natl Acad Sci U S A Date: 2011-08-29 Impact factor: 11.205

5. The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function.

Authors: Andrew N Macintyre; Valerie A Gerriets; Amanda G Nichols; Ryan D Michalek; Michael C Rudolph; Divino Deoliveira; Steven M Anderson; E Dale Abel; Benny J Chen; Laura P Hale; Jeffrey C Rathmell
Journal: Cell Metab Date: 2014-06-12 Impact factor: 27.287

Review 6. Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes.

Authors: Jean-Pierre Etchegaray; Raul Mostoslavsky
Journal: Mol Cell Date: 2016-06-02 Impact factor: 17.970

Review 7. Epigenetic control of interferon-gamma expression in CD8 T cells.

Authors: Patrícia S de Araújo-Souza; Steffi C H Hanschke; João P B Viola
Journal: J Immunol Res Date: 2015-04-20 Impact factor: 4.818

8. Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.

Authors: Ping-Chih Ho; Jessica Dauz Bihuniak; Andrew N Macintyre; Matthew Staron; Xiaojing Liu; Robert Amezquita; Yao-Chen Tsui; Guoliang Cui; Goran Micevic; Jose C Perales; Steven H Kleinstein; E Dale Abel; Karl L Insogna; Stefan Feske; Jason W Locasale; Marcus W Bosenberg; Jeffrey C Rathmell; Susan M Kaech
Journal: Cell Date: 2015-08-27 Impact factor: 41.582

9. The rate of glycolysis quantitatively mediates specific histone acetylation sites.

Authors: Ahmad A Cluntun; He Huang; Lunzhi Dai; Xiaojing Liu; Yingming Zhao; Jason W Locasale
Journal: Cancer Metab Date: 2015-09-23

9 in total

1. A genetic screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation.

Authors: Michael C Kiritsy; Laurisa M Ankley; Justin Trombley; Gabrielle P Huizinga; Audrey E Lord; Pontus Orning; Roland Elling; Katherine A Fitzgerald; Andrew J Olive
Journal: Elife Date: 2021-11-08 Impact factor: 8.140

2. LKB1-PTEN axis controls Th1 and Th17 cell differentiation via regulating mTORC1.

Authors: Mahesh Pandit; Maheshwor Timilshina; Jae-Hoon Chang
Journal: J Mol Med (Berl) Date: 2021-05-18 Impact factor: 4.599

Review 3. The Peripheral and Intratumoral Immune Cell Landscape in Cancer Patients: A Proxy for Tumor Biology and a Tool for Outcome Prediction.

Authors: Annette Schnell; Christian Schmidl; Wolfgang Herr; Peter J Siska
Journal: Biomedicines Date: 2018-02-24

4. Differential Reliance on Lipid Metabolism as a Salvage Pathway Underlies Functional Differences of T Cell Subsets in Poor Nutrient Environments.

Authors: Christopher Ecker; Lili Guo; Stefana Voicu; Luis Gil-de-Gómez; Andrew Medvec; Luis Cortina; Jackie Pajda; Melanie Andolina; Maria Torres-Castillo; Jennifer L Donato; Sarya Mansour; Evan R Zynda; Pei-Yi Lin; Angel Varela-Rohena; Ian A Blair; James L Riley
Journal: Cell Rep Date: 2018-04-17 Impact factor: 9.423

8. Immune and Metabolic Dysregulated Coding and Non-coding RNAs Reveal Survival Association in Uterine Corpus Endometrial Carcinoma.

Authors: Da Liu; Min Qiu
Journal: Front Genet Date: 2021-06-24 Impact factor: 4.599

Review 9. Metabolic Modifications by Common Respiratory Viruses and Their Potential as New Antiviral Targets.

Authors: Jens Kleinehr; Janine J Wilden; Yvonne Boergeling; Stephan Ludwig; Eike R Hrincius
Journal: Viruses Date: 2021-10-14 Impact factor: 5.048

9 in total

Metabolic Signaling Drives IFN-γ.

Review 1. Metabolic control of epigenetics in cancer.

2. LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.

3. Posttranscriptional control of T cell effector function by aerobic glycolysis.

4. Differentiation-dependent functional and epigenetic landscapes for cytokine genes in virus-specific CD8+ T cells.

5. The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function.

Review 6. Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes.

Review 7. Epigenetic control of interferon-gamma expression in CD8 T cells.

8. Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.

9. The rate of glycolysis quantitatively mediates specific histone acetylation sites.

1. A genetic screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation.

2. LKB1-PTEN axis controls Th1 and Th17 cell differentiation via regulating mTORC1.

Review 3. The Peripheral and Intratumoral Immune Cell Landscape in Cancer Patients: A Proxy for Tumor Biology and a Tool for Outcome Prediction.

4. Differential Reliance on Lipid Metabolism as a Salvage Pathway Underlies Functional Differences of T Cell Subsets in Poor Nutrient Environments.

5. Sirtuin1 Targeting Reverses Innate and Adaptive Immune Tolerance in Septic Mice.

6. Lactation stage impacts the glycolytic function of bovine CD4⁺ T cells during ex vivo activation.

7. The immunologic changes during different phases of intestinal anastomotic healing.

8. Immune and Metabolic Dysregulated Coding and Non-coding RNAs Reveal Survival Association in Uterine Corpus Endometrial Carcinoma.

Review 9. Metabolic Modifications by Common Respiratory Viruses and Their Potential as New Antiviral Targets.