Literature DB >> 27829132

Arginine Arms T Cells to Thrive and Survive.

Rigel J Kishton1, Madhusudhanan Sukumar1, Nicholas P Restifo2.   

Abstract

A clear role for cellular metabolism in regulating immune cell function has recently been established. In a recent issue of Cell, Geiger et al. (2016) demonstrate a role for intracellular arginine abundance in T cells for the promotion of oxidative metabolism, increased cell viability, persistence, and in vivo antitumor response. Published by Elsevier Inc.

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Year:  2016        PMID: 27829132      PMCID: PMC6327309          DOI: 10.1016/j.cmet.2016.10.019

Source DB:  PubMed          Journal:  Cell Metab        ISSN: 1550-4131            Impact factor:   27.287


  3 in total

Review 1.  Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy.

Authors:  Weimin Wang; Weiping Zou
Journal:  Mol Cell       Date:  2020-09-29       Impact factor: 17.970

2.  Efficient Induction of Antigen-Specific CD8+ T-Cell Responses by Cationic Peptide-Based mRNA Nanoparticles.

Authors:  Sigrid D'haese; Thessa Laeremans; Sabine den Roover; Sabine D Allard; Guido Vanham; Joeri L Aerts
Journal:  Pharmaceutics       Date:  2022-06-30       Impact factor: 6.525

3.  Safety, PK/PD and preliminary anti-tumor activities of pegylated recombinant human arginase 1 (BCT-100) in patients with advanced arginine auxotrophic tumors.

Authors:  Paul N M Cheng; Angela M Liu; Alberto Bessudo; Francis Mussai
Journal:  Invest New Drugs       Date:  2021-07-21       Impact factor: 3.850

  3 in total

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