Literature DB >> 27826843

Structure and Function of TET Enzymes.

Xiaotong Yin1, Yanhui Xu2,3,4.   

Abstract

Mammalian DNA methylation mainly occurs at the carbon-C5 position of cytosine (5mC). TET enzymes were discovered to successively oxidize 5mC to 5-hydromethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). TET enzymes and oxidized 5mC derivatives play important roles in various biological and pathological processes, including regulation of DNA demethylation, gene transcription, embryonic development, and oncogenesis. In this chapter, we will discuss the discovery of TET-mediated 5mC oxidation and the structure, function, and regulation of TET enzymes.

Entities:  

Keywords:  DNA demethylation; Epigenetic modification; TET

Mesh：

Substances：

Year:  2016        PMID： 27826843     DOI： 10.1007/978-3-319-43624-1_12

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  11 in total

Review 1.  Targeting the epigenome in malignant pleural mesothelioma.

Authors:  Kaitlin C McLoughlin; Andrew S Kaufman; David S Schrump
Journal:  Transl Lung Cancer Res       Date:  2017-06

2.  CD44s is a crucial ATG7 downstream regulator for stem-like property, invasion, and lung metastasis of human bladder cancer (BC) cells.

Authors:  Junlan Zhu; Grace Huang; Xiaohui Hua; Yang Li; Huiying Yan; Xun Che; Zhongxian Tian; Huating Liufu; Chao Huang; Jingxia Li; Jiheng Xu; Wei Dai; Haishan Huang; Chuanshu Huang
Journal:  Oncogene       Date:  2019-01-11       Impact factor: 9.867

3.  D-2-Hydroxyglutarate Is Necessary and Sufficient for Isocitrate Dehydrogenase 1 Mutant-Induced MIR148A Promoter Methylation.

Authors:  Tie Li; Christopher D Cox; Byram H Ozer; Nhung T Nguyen; HuyTram N Nguyen; Thomas J Lai; Sichen Li; Fei Liu; Harley I Kornblum; Linda M Liau; Phioanh L Nghiemphu; Timothy F Cloughesy; Albert Lai
Journal:  Mol Cancer Res       Date:  2018-03-15       Impact factor: 5.852

4.  Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors.

Authors:  Kasper Fugger; Ilirjana Bajrami; Mariana Silva Dos Santos; Sarah Jane Young; Simone Kunzelmann; Geoff Kelly; Graeme Hewitt; Harshil Patel; Robert Goldstone; Thomas Carell; Simon J Boulton; James MacRae; Ian A Taylor; Stephen C West
Journal:  Science       Date:  2021-04-09       Impact factor: 47.728

5.  Silencing of the TRIM58 Gene by Aberrant Promoter Methylation is Associated with a Poor Patient Outcome and Promotes Cell Proliferation and Migration in Clear Cell Renal Cell Carcinoma.

Authors:  Ying Gan; Congcong Cao; Aolin Li; Haifeng Song; Guanyu Kuang; Binglei Ma; Quan Zhang; Qian Zhang
Journal:  Front Mol Biosci       Date:  2021-03-16

6.  Flanking sequences influence the activity of TET1 and TET2 methylcytosine dioxygenases and affect genomic 5hmC patterns.

Authors:  Sabrina Adam; Julia Bräcker; Viviane Klingel; Bernd Osteresch; Nicole E Radde; Jens Brockmeyer; Pavel Bashtrykov; Albert Jeltsch
Journal:  Commun Biol       Date:  2022-01-24

Review 7.  The Role of Ten-Eleven Translocation Proteins in Inflammation.

Authors:  Christian Gerecke; Caue Egea Rodrigues; Thomas Homann; Burkhard Kleuser
Journal:  Front Immunol       Date:  2022-03-21       Impact factor: 7.561

8.  The Potential Role of Epigenetic Mechanisms in the Development of Retinitis Pigmentosa and Related Photoreceptor Dystrophies.

Authors:  Galina Dvoriantchikova; Karin Rose Lypka; Dmitry Ivanov
Journal:  Front Genet       Date:  2022-03-11       Impact factor: 4.599

Review 9.  DNA methylation/hydroxymethylation in melanoma.

Authors:  Siqi Fu; Haijing Wu; Huiming Zhang; Christine G Lian; Qianjin Lu
Journal:  Oncotarget       Date:  2017-05-30

Review 10.  RNA editing in mesothelioma: a look forward.

Authors:  Ananya Hariharan; Suna Sun; Martin Wipplinger; Emanuela Felley-Bosco
Journal:  Open Biol       Date:  2020-10-14       Impact factor: 6.411
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.