Meral Gunaldi1, Dilek Erdem2, Sema Goksu3, Seyda Gunduz4, Yildiz Okuturlar5, Eda Tiken6, Huseyin Aksoy7, Mustafa Yildirim4. 1. Department of Medical Oncology, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Bakirkoy, Istanbul, Turkey. meralgunaldi@gmail.com. 2. Department of Medical Oncology, Samsun Medical Park Hospital, Samsun, Turkey. 3. Department of Medical Oncology, Kayseri Education and Research Hospital, Kayseri, Turkey. 4. Department of Medical Oncology, Antalya Education and Research Hospital, Antalya, Turkey. 5. Department of Internal Medicine, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey. 6. Department of Radiation Oncology, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey. 7. Department of General Surgery, GATA Haydarpasa Education Hospital, Istanbul, Turkey.
Abstract
INTRODUCTION: There are few known predictors of gastric cancer (GC). In this study, we evaluated the relationship between peripheral blood parameters and disease in patients with GC. Our aim was to identify a predictor of the development of metastasis. MATERIALS AND METHODS: Pretreatment peripheral blood parameters, including neutrophil, lymphocyte, and platelet counts; median platelet values (MPVs); and platelet distribution width (PDW), of patients diagnosed with GC were assessed. The independent T test was used in comparisons between two groups with a normal distribution, the Mann-Whitney U test in comparisons between two groups without a normal distribution, the Kruskal-Wallis test to compare more than two groups, and the Dunn's multiple comparison test to compare subgroups. A p value <0.05 was considered statistically significant. RESULTS: In GC patients, neutrophil and platelet counts, but not lymphocyte counts and MPVs, increased significantly with disease stage progression. Among patients who developed a metastasis during follow-up, the relationship between PDW and the risk of metastasis was statistically significant (p = 0.04). Both lymphocyte and platelet levels had a statistically significant relationship to survival (p = 0.04 and p = 0.02, respectively). CONCLUSIONS: Our results showed that in patients with GC, PDW, one of the standard parameters measured in a complete blood count, is a predictor of metastasis. Therefore, the PDW may be an important consideration in the surgical and chemotherapeutic treatment planning of patients with GC. Treatment strategies should also take into account lymphocyte and platelet levels, both of which were shown to be significantly related to survival.
INTRODUCTION: There are few known predictors of gastric cancer (GC). In this study, we evaluated the relationship between peripheral blood parameters and disease in patients with GC. Our aim was to identify a predictor of the development of metastasis. MATERIALS AND METHODS: Pretreatment peripheral blood parameters, including neutrophil, lymphocyte, and platelet counts; median platelet values (MPVs); and platelet distribution width (PDW), of patients diagnosed with GC were assessed. The independent T test was used in comparisons between two groups with a normal distribution, the Mann-Whitney U test in comparisons between two groups without a normal distribution, the Kruskal-Wallis test to compare more than two groups, and the Dunn's multiple comparison test to compare subgroups. A p value <0.05 was considered statistically significant. RESULTS: In GC patients, neutrophil and platelet counts, but not lymphocyte counts and MPVs, increased significantly with disease stage progression. Among patients who developed a metastasis during follow-up, the relationship between PDW and the risk of metastasis was statistically significant (p = 0.04). Both lymphocyte and platelet levels had a statistically significant relationship to survival (p = 0.04 and p = 0.02, respectively). CONCLUSIONS: Our results showed that in patients with GC, PDW, one of the standard parameters measured in a complete blood count, is a predictor of metastasis. Therefore, the PDW may be an important consideration in the surgical and chemotherapeutic treatment planning of patients with GC. Treatment strategies should also take into account lymphocyte and platelet levels, both of which were shown to be significantly related to survival.
Entities:
Keywords:
Chemotherapy; Gastric cancer; Metastasis; Platelet distribution; Predictive value
Authors: Mehmet Aliustaoglu; Ahmet Bilici; Bala Basak Oven Ustaalioglu; Volkan Konya; Murat Gucun; Mesut Seker; Mahmut Gumus Journal: Med Oncol Date: 2009-10-22 Impact factor: 3.064
Authors: Qing-Qing Li; Zhi-Hao Lu; Li Yang; Ming Lu; Xiao-Tian Zhang; Jian Li; Jun Zhou; Xi-Cheng Wang; Ji-Fang Gong; Jing Gao; Jie Li; Yan Li; Lin Shen Journal: Asian Pac J Cancer Prev Date: 2014
Authors: D Liu; Z F Xu; P H Zhang; J Ma; T J Qin; S Q Qu; X J Sun; B Li; L J Pan; Y J Jia; Z J Xiao Journal: Zhonghua Xue Ye Xue Za Zhi Date: 2021-11-14