Literature DB >> 27823920

"Hepatocellular carcinoma: A life-threatening disease".

Shinu Chacko1, Subir Samanta2.   

Abstract

An estimated rise in liver cancer incidence will increase to 95374 new cases by 2020. Hepatocellular Carcinoma (HCC), the most common primary malignant tumour of the liver, is considered to be the third leading cause of all cancer-related deaths and fifth common cancer worldwide. The reported data shows that the rate of HCC incidence in male population is three to four times higher compared with the female population. In the United States, HCV-induced liver cancer is increasing very fast because of the lack of proper treatment option. There are various treatment strategies available for HCC like liver transplantation, resection, ablation, embolization and chemotherapy still the prognosis is destitute. If the patient is eligible, liver transplantation is the only therapeutic option that may give around 90% survival rate, but the scarcity of liver donor limits its broad applicability. A sudden address is necessary to develop specific drugs, personalized medicine, for HCC.
Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Hepatocellular carcinoma; Immunotherapy; Molecular targeted therapy; Peptide hybrid; Personalized medicine; Transarterial chemoembolization

Mesh:

Substances:

Year:  2016        PMID: 27823920     DOI: 10.1016/j.biopha.2016.10.078

Source DB:  PubMed          Journal:  Biomed Pharmacother        ISSN: 0753-3322            Impact factor:   6.529


  34 in total

1.  Phase I/II study of first-line combination therapy with sorafenib plus resminostat, an oral HDAC inhibitor, versus sorafenib monotherapy for advanced hepatocellular carcinoma in east Asian patients.

Authors:  Won Young Tak; Baek-Yeol Ryoo; Ho Yeong Lim; Do-Young Kim; Takuji Okusaka; Masafumi Ikeda; Hisashi Hidaka; Jong-Eun Yeon; Eishiro Mizukoshi; Manabu Morimoto; Myung-Ah Lee; Kohichiroh Yasui; Yasunori Kawaguchi; Jeong Heo; Sojiro Morita; Tae-You Kim; Junji Furuse; Kazuhiro Katayama; Takeshi Aramaki; Rina Hara; Takuya Kimura; Osamu Nakamura; Masatoshi Kudo
Journal:  Invest New Drugs       Date:  2018-09-10       Impact factor: 3.850

2.  Outcomes Following Resection of Hepatocellular Carcinoma in the Absence of Cirrhosis.

Authors:  Richard H Lewis; Evan S Glazer; David M Bittenbinder; Thomas O'Brien; Jeremiah L Deneve; David Shibata; Stephen W Behrman; Jason M Vanatta; Sanjaya K Satapathy; Paxton V Dickson
Journal:  J Gastrointest Cancer       Date:  2019-12

3.  The clinical significance and biological function of large tumour suppressor 2 in hepatocellular carcinoma.

Authors:  Rong Liang; Yan Lin; Chun-Ling Yuan; Zhi-Hui Liu; Yong-Qiang Li; Xiao-Ling Luo; Jia-Zhou Ye; Hai-Hong Ye
Journal:  Cell Prolif       Date:  2017-03-01       Impact factor: 6.831

4.  Five Novel Oncogenic Signatures Could Be Utilized as AFP-Related Diagnostic Biomarkers for Hepatocellular Carcinoma Based on Next-Generation Sequencing.

Authors:  Zheng Yu; Rongchang Wang; Fan Chen; Jianru Wang; Xiaohui Huang
Journal:  Dig Dis Sci       Date:  2018-02-13       Impact factor: 3.199

Review 5.  The combination of transcatheter arterial chemoembolisation (TACE) and thermal ablation versus TACE alone for hepatocellular carcinoma.

Authors:  BoZhi Liu; YongChao Zhang; Hui Chen; Wei Li; Emmanuel Tsochatzis
Journal:  Cochrane Database Syst Rev       Date:  2022-01-04

6.  A proteomics-based investigation on the anticancer activity of alisertib, an Aurora kinase A inhibitor, in hepatocellular carcinoma Hep3B cells.

Authors:  Qiaohua Zhu; Meihua Luo; Chengyu Zhou; Zhiwei Zhou; Zhixu He; Xinfa Yu; Shufeng Zhou
Journal:  Am J Transl Res       Date:  2017-08-15       Impact factor: 4.060

7.  Combined Inhibition of TGF-β1-Induced EMT and PD-L1 Silencing Re-Sensitizes Hepatocellular Carcinoma to Sorafenib Treatment.

Authors:  Ritu Shrestha; Prashanth Prithviraj; Kim R Bridle; Darrell H G Crawford; Aparna Jayachandran
Journal:  J Clin Med       Date:  2021-04-27       Impact factor: 4.241

Review 8.  Dairy consumption and hepatocellular carcinoma risk.

Authors:  Bodo C Melnik
Journal:  Ann Transl Med       Date:  2021-04

9.  Anti-angiogenesis and anti-metastasis effects of Polyphyllin VII on Hepatocellular carcinoma cells in vitro and in vivo.

Authors:  Chao Zhang; Qingrui Li; Guozheng Qin; Yi Zhang; Chaoying Li; Liwen Han; Rongchun Wang; Shudan Wang; Haixia Chen; Kechun Liu; Chengwei He
Journal:  Chin Med       Date:  2021-05-31       Impact factor: 5.455

Review 10.  Histotripsy Ablation in Preclinical Animal Models of Cancer and Spontaneous Tumors in Veterinary Patients: A Review.

Authors:  Alissa Hendricks-Wenger; Lauren Arnold; Jessica Gannon; Alex Simon; Neha Singh; Hannah Sheppard; Margaret A Nagai-Singer; Khan Mohammad Imran; Kiho Lee; Sherrie Clark-Deener; Christopher Byron; Michael R Edwards; Martha M Larson; John H Rossmeisl; Sheryl L Coutermarsh-Ott; Kristin Eden; Nikolaos Dervisis; Shawna Klahn; Joanne Tuohy; Irving Coy Allen; Eli Vlaisavljevich
Journal:  IEEE Trans Ultrason Ferroelectr Freq Control       Date:  2021-12-31       Impact factor: 3.267

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