Literature DB >> 27823882

Novel hamamelitannin analogues for the treatment of biofilm related MRSA infections-A scaffold hopping approach.

Arno Vermote1, Gilles Brackman2, Martijn D P Risseeuw1, Tom Coenye2, Serge Van Calenbergh3.   

Abstract

Antimicrobial research is increasingly being focused on the problem of resistance and biofilm formation. Hamamelitannin (HAM) was recently identified as an antimicrobial potentiator for conventional antibiotics towards Staphylococcus aureus. This paper describes the synthesis and biological evaluation of novel hamamelitannin analogues with alternative central scaffolds. Via a ligand-based approach, several interesting compounds with improved synthetic accessibility were identified as potentiators for vancomycin in the treatment of MRSA infections.
Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Antibiotic potentiators; Hamamelitannin analogues; MRSA; Quorum sensing; Scaffold hopping

Mesh：

Substances：

Year:  2016        PMID： 27823882     DOI： 10.1016/j.ejmech.2016.10.056

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  11 in total

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Authors:  Akram M Salam; Cassandra L Quave
Journal:  Curr Opin Microbiol       Date:  2018-09-13       Impact factor: 7.934

3.  Expanding the Spectrum of Antibiotics Capable of Killing Multidrug-Resistant Staphylococcus aureus and Pseudomonas aeruginosa.

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Journal:  Molecules       Date:  2018-05-04       Impact factor: 4.411

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7.  Screening of Natural Product Derivatives Identifies Two Structurally Related Flavonoids as Potent Quorum Sensing Inhibitors against Gram-Negative Bacteria.

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Journal:  Int J Mol Sci       Date:  2018-05-03       Impact factor: 5.923

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9.  In-Vitro Inhibition of Staphylococcal Pathogenesis by Witch-Hazel and Green Tea Extracts.

Authors:  Reuven Rasooly; Adel Molnar; Hwang-Yong Choi; Paula Do; Kenneth Racicot; Emmanouil Apostolidis
Journal:  Antibiotics (Basel)       Date:  2019-11-29

Review 10.  Strategies and Approaches for Discovery of Small Molecule Disruptors of Biofilm Physiology.

Authors:  Michael A Trebino; Rahul D Shingare; John B MacMillan; Fitnat H Yildiz
Journal:  Molecules       Date:  2021-07-29       Impact factor: 4.411
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