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Literature DB >> 27823881

Aliphatic and alicyclic camphor imines as effective inhibitors of influenza virus H1N1.

Anastasiya S Sokolova¹, Оlga I Yarovaya², Dmitry S Baev³, Аndrey V Shernyukov³, Anna A Shtro⁴, Vladimir V Zarubaev⁵, Nariman F Salakhutdinov¹.

Abstract

A series of camphor derived imines was synthesised and evaluated in vitro for antiviral activity. Theoretical evaluations of ADME properties were also carried out. Most of these compounds exhibited significant activity against the drug-resistant strains of influenza A virus. Especially, compounds 2 (SI = 632) and 3 (SI = 417) presented high inhibition against influenza subtypes A/Puerto Rico/8/34 and A/California/07/09 of H1N1pdm09. Analysis of the structure-activity relationship showed that the activity was strongly dependent on the length of the aliphatic chain: derivatives with a shorter chain possessed higher activity, while the suppressing action of compounds with long aliphatic chains was lower.

Entities: Chemical Species

Keywords: Antiviral; Cage compounds; Camphor derivatives; Influenza

Mesh：

Substances：

Year: 2016 PMID： 27823881 DOI： 10.1016/j.ejmech.2016.10.035

Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514

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Cited

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10 in total

Aliphatic and alicyclic camphor imines as effective inhibitors of influenza virus H1N1.

1. New chemical agents based on adamantane-monoterpene conjugates against orthopoxvirus infections.

2. Synthesis of d-(+)-camphor-based N-acylhydrazones and their antiviral activity.

3. Quaternary ammonium salts based on (-)-borneol as effective inhibitors of influenza virus.

4. Discovery of New Ginsenol-Like Compounds with High Antiviral Activity.

5. Borneol Ester Derivatives as Entry Inhibitors of a Wide Spectrum of SARS-CoV-2 Viruses.

6. N-Heterocyclic borneol derivatives as inhibitors of Marburg virus glycoprotein-mediated VSIV pseudotype entry.

7. Synthesis and in vitro study of novel borneol derivatives as potent inhibitors of the influenza A virus.

Review 8. Silver Camphor Imine Complexes: Novel Antibacterial Compounds from Old Medicines.

Review 9. Monoterpenes and Their Derivatives-Recent Development in Biological and Medical Applications.

10. Modelling the DFT structural and reactivity study of feverfew and evaluation of its potential antiviral activity against COVID-19 using molecular docking and MD simulations.