Literature DB >> 27823878

Prodrug approach: An overview of recent cases.

Valentina Abet1, Fabiana Filace1, Javier Recio1, Julio Alvarez-Builla2, Carolina Burgos3.   

Abstract

In this review we highlight the most modern trends in the prodrug strategy. In drug research and development, the prodrug concept has found a number of useful applications. Selected examples of this approach are provided in this paper and they are classified according to the aim of their design.
Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Keywords:  Bioprecursors; Carrier-linked prodrug; Prodrug

Mesh：

Substances：

Year:  2016        PMID： 27823878     DOI： 10.1016/j.ejmech.2016.10.061

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  18 in total

1.  Conjugates of 3-phenyllactic acid and tryptophan enhance root-promoting activity without adverse effects in Vigna angularis.

Authors:  Yuko Maki; Hiroshi Soejima; Tamizi Sugiyama; Takeo Sato; Junji Yamaguchi; Masaaki K Watahiki
Journal:  Plant Biotechnol (Tokyo)       Date:  2022-06-25       Impact factor: 1.308

2.  Improving the oral bioavailability of tapentadol via a carbamate prodrug approach: synthesis, bioactivation, and pharmacokinetics.

Authors:  Yingchao Li; Yongjun Wang; Ran Zhang; Cuiru Liu; Yue Wei; Jin Sun; Zhonggui He; Youjun Xu; Tianhong Zhang
Journal:  Drug Deliv Transl Res       Date:  2018-10       Impact factor: 4.617

3.  A highly GSH-sensitive SN-38 prodrug with an "OFF-to-ON" fluorescence switch as a bifunctional anticancer agent.

Authors:  Chang-Hee Whang; Eunsoo Yoo; Seong Kwon Hur; Kyeong Soo Kim; Dongin Kim; Seongbong Jo
Journal:  Chem Commun (Camb)       Date:  2018-07-26       Impact factor: 6.222

Review 4.  Microbial esterases and ester prodrugs: An unlikely marriage for combating antibiotic resistance.

Authors:  Erik M Larsen; R Jeremy Johnson
Journal:  Drug Dev Res       Date:  2018-10-10       Impact factor: 4.360

Review 5.  Toxicity mechanism-based prodrugs: glutathione-dependent bioactivation as a strategy for anticancer prodrug design.

Authors:  Xin-Yu Zhang; Adnan A Elfarra
Journal:  Expert Opin Drug Discov       Date:  2018-08-13       Impact factor: 6.098

6.  Semisynthetic Derivatives of the Verticillin Class of Natural Products through Acylation of the C11 Hydroxy Group.

Authors:  Chiraz Soumia M Amrine; Andrew C Huntsman; Michael G Doyle; Joanna E Burdette; Cedric J Pearce; James R Fuchs; Nicholas H Oberlies
Journal:  ACS Med Chem Lett       Date:  2021-03-19       Impact factor: 4.345

7.  Protective Effects of a Lutein Ester Prodrug, Lutein Diglutaric Acid, against H2O2-Induced Oxidative Stress in Human Retinal Pigment Epithelial Cells.

Authors:  Chawanphat Muangnoi; Rianthong Phumsuay; Nattapong Jongjitphisut; Pasin Waikasikorn; Monsin Sangsawat; Paitoon Rashatasakhon; Luminita Paraoan; Pornchai Rojsitthisak
Journal:  Int J Mol Sci       Date:  2021-04-29       Impact factor: 5.923

Review 8.  Disulfide based prodrugs for cancer therapy.

Authors:  Qiang Wang; Jiankun Guan; Jiangling Wan; Zifu Li
Journal:  RSC Adv       Date:  2020-06-25       Impact factor: 4.036

Review 9.  Recent Advances in the Application of Vitamin E TPGS for Drug Delivery.

Authors:  Conglian Yang; Tingting Wu; Yan Qi; Zhiping Zhang
Journal:  Theranostics       Date:  2018-01-01       Impact factor: 11.556

10.  Synthesis of Novel Acyl Derivatives of 3-(4,5,6,7-Tetrabromo-1H-benzimidazol-1-yl)propan-1-ols-Intracellular TBBi-Based CK2 Inhibitors with Proapoptotic Properties.

Authors:  Konrad Chojnacki; Patrycja Wińska; Olena Karatsai; Mirosława Koronkiewicz; Małgorzata Milner-Krawczyk; Monika Wielechowska; Maria Jolanta Rędowicz; Maria Bretner; Paweł Borowiecki
Journal:  Int J Mol Sci       Date:  2021-06-10       Impact factor: 5.923
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.