Signe S Risom1, Ann-Dorthe Zwisler2, Trine B Rasmussen3, Kirstine Lærum Sibilitz4, Trine L S Madsen5, Jesper Hastrup Svendsen6, Christian Gluud7, Jane Lindschou7, Per Winkel7, Selina Kikkenborg Berg8. 1. Rigshospitalet, The Heart Centre, Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark; Department of Nursing, Faculty of Health and Technology, Metropolitan University College, Copenhagen, Denmark. Electronic address: Signe.stelling.risom@regionh.dk. 2. Rigshospitalet, The Heart Centre, Copenhagen University Hospital, Copenhagen, Denmark; National Centre of Rehabilitation and Palliation, University of Southern Denmark, Odense University Hospital, Odense C, Denmark; National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark. 3. Rigshospitalet, The Heart Centre, Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark; Department of Cardiology, Herlev and Gentofte Hospital, Hellerup, Denmark. 4. Rigshospitalet, The Heart Centre, Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark. 5. Department of Nursing, Faculty of Health and Technology, Metropolitan University College, Copenhagen, Denmark. 6. Rigshospitalet, The Heart Centre, Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark; The Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Copenhagen, Denmark. 7. Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Denmark. 8. Rigshospitalet, The Heart Centre, Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark; National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
Abstract
BACKGROUND: To assess the effects of comprehensive cardiac rehabilitation compared with usual care on physical activity and mental health for patients treated with catheter ablation for atrial fibrillation. METHODS: The patients were randomized 1:1 stratified by paroxysmal or persistent atrial fibrillation and sex to cardiac rehabilitation consisting of 12 weeks physical exercise and four psycho-educational consultations plus usual care (cardiac rehabilitation group) versus usual care. The primary outcome was Vo2 peak. The secondary outcome was self-rated mental health measured by the Short Form-36 questionnaire. Exploratory outcomes were collected. RESULTS:210 patients were included (mean age: 59 years, 74% men), 72% had paroxysmal atrial fibrillation prior to ablation. Compared with usual care, the cardiac rehabilitation group had a beneficial effect on Vo2 peak at four months (24.3mL kg-1 min-1 versus 20.7mL kg-1 min-1, p of main effect=0.003, p of interaction between time and intervention=0.020). No significant difference between groups on Short Form-36 was found (53.8 versus 51.9 points, P=.20). Two serious adverse events (atrial fibrillation in relation to physical exercise and death unrelated to rehabilitation) occurred in the cardiac rehabilitation group versus one in the usual care group (death unrelated to intervention) (P=.56). In the cardiac rehabilitation group 16 patients versus 7 in the usual care group reported non-serious adverse events (P=.047). CONCLUSION:Comprehensive cardiac rehabilitation had a positive effect on physical capacity compared with usual care, but not on mental health. Cardiac rehabilitation caused more non-serious adverse events.
RCT Entities:
BACKGROUND: To assess the effects of comprehensive cardiac rehabilitation compared with usual care on physical activity and mental health for patients treated with catheter ablation for atrial fibrillation. METHODS: The patients were randomized 1:1 stratified by paroxysmal or persistent atrial fibrillation and sex to cardiac rehabilitation consisting of 12 weeks physical exercise and four psycho-educational consultations plus usual care (cardiac rehabilitation group) versus usual care. The primary outcome was Vo2 peak. The secondary outcome was self-rated mental health measured by the Short Form-36 questionnaire. Exploratory outcomes were collected. RESULTS: 210 patients were included (mean age: 59 years, 74% men), 72% had paroxysmal atrial fibrillation prior to ablation. Compared with usual care, the cardiac rehabilitation group had a beneficial effect on Vo2 peak at four months (24.3mL kg-1 min-1 versus 20.7mL kg-1 min-1, p of main effect=0.003, p of interaction between time and intervention=0.020). No significant difference between groups on Short Form-36 was found (53.8 versus 51.9 points, P=.20). Two serious adverse events (atrial fibrillation in relation to physical exercise and death unrelated to rehabilitation) occurred in the cardiac rehabilitation group versus one in the usual care group (death unrelated to intervention) (P=.56). In the cardiac rehabilitation group 16 patients versus 7 in the usual care group reported non-serious adverse events (P=.047). CONCLUSION: Comprehensive cardiac rehabilitation had a positive effect on physical capacity compared with usual care, but not on mental health. Cardiac rehabilitation caused more non-serious adverse events.
Authors: Neil A Smart; Nicola King; Jeffrey D Lambert; Melissa J Pearson; John L Campbell; Signe S Risom; Rod S Taylor Journal: Open Heart Date: 2018-12-20
Authors: Jonas Zacher; Katrin Dillschnitter; Hans-Georg Predel; Moritz Schumann; Nils Freitag; Thorsten Kreutz; Birna Bjarnason-Wehrens; Wilhelm Bloch Journal: BMJ Open Date: 2020-10-31 Impact factor: 2.692
Authors: Emelia J Benjamin; Sana M Al-Khatib; Patrice Desvigne-Nickens; Alvaro Alonso; Luc Djoussé; Daniel E Forman; Anne M Gillis; Jeroen M L Hendriks; Mellanie True Hills; Paulus Kirchhof; Mark S Link; Gregory M Marcus; Reena Mehra; Katherine T Murray; Ratika Parkash; Ileana L Piña; Susan Redline; Michiel Rienstra; Prashanthan Sanders; Virend K Somers; David R Van Wagoner; Paul J Wang; Lawton S Cooper; Alan S Go Journal: J Am Heart Assoc Date: 2021-08-05 Impact factor: 6.106