Daniel Rinnström1, Mikael Dellborg2, Ulf Thilén3, Peder Sörensson4, Niels-Erik Nielsen5, Christina Christersson6, Bengt Johansson7. 1. Heart Centre and Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden. Electronic address: dan_r_82@hotmail.com. 2. Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden. 3. Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden. 4. Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. 5. Department of Medical and Health Sciences, Linköping University, Linköping, Sweden. 6. Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden. 7. Heart Centre and Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Abstract
AIMS: In adults with coarctation of the aorta (CoA), hypertension (HTN) is a common long-term complication. We investigated the prevalence of HTN and analyzed factors associated with HTN. METHODS AND RESULTS: In the national register for congenital heart disease, 653 adults with repaired CoA were identified (mean age 36.9±14.4years); 344 (52.7%) of them had HTN, defined as either an existing diagnosis or blood pressure (BP) ≥140/90mmHg at the clinical visit. In a multivariable model, age (years) (odds ratio [OR] 1.07, CI 1.05-1.10), sex (male) (OR 3.35, CI 1.98-5.68), and body mass index (kilograms per square meter) (OR 1.09, CI 1.03-1.16) were independently associated with having HTN, and so was systolic arm-leg BP gradient where an association with HTN was found at the ranges of (10, 20] and >20mmHg, in comparison to the interval ≤10mmHg (OR 3.58, CI 1.70-7.55, and OR 11.38, CI 4.03-32.11). This model remained valid when all patients who had increased BP (≥140/90mmHg) without having been diagnosed with HTN were excluded from the analyses. CONCLUSIONS: Hypertension is common in patients with previously repaired CoA and is associated with increasing age, male sex, and elevated body mass index. There is also an association with arm-leg BP gradient, starting at relatively low levels that are usually not considered for intervention.
AIMS: In adults with coarctation of the aorta (CoA), hypertension (HTN) is a common long-term complication. We investigated the prevalence of HTN and analyzed factors associated with HTN. METHODS AND RESULTS: In the national register for congenital heart disease, 653 adults with repaired CoA were identified (mean age 36.9±14.4years); 344 (52.7%) of them had HTN, defined as either an existing diagnosis or blood pressure (BP) ≥140/90mmHg at the clinical visit. In a multivariable model, age (years) (odds ratio [OR] 1.07, CI 1.05-1.10), sex (male) (OR 3.35, CI 1.98-5.68), and body mass index (kilograms per square meter) (OR 1.09, CI 1.03-1.16) were independently associated with having HTN, and so was systolic arm-leg BP gradient where an association with HTN was found at the ranges of (10, 20] and >20mmHg, in comparison to the interval ≤10mmHg (OR 3.58, CI 1.70-7.55, and OR 11.38, CI 4.03-32.11). This model remained valid when all patients who had increased BP (≥140/90mmHg) without having been diagnosed with HTN were excluded from the analyses. CONCLUSIONS:Hypertension is common in patients with previously repaired CoA and is associated with increasing age, male sex, and elevated body mass index. There is also an association with arm-leg BP gradient, starting at relatively low levels that are usually not considered for intervention.
Authors: Trisha V Vigneswaran; Manish D Sinha; Israel Valverde; John M Simpson; Marietta Charakida Journal: Pediatr Cardiol Date: 2017-10-17 Impact factor: 1.655
Authors: E G Warmerdam; G J Krings; T A Meijs; A C Franken; B W Driesen; G T Sieswerda; F J Meijboom; P A F Doevendans; M M C Molenschot; M Voskuil Journal: Neth Heart J Date: 2020-03 Impact factor: 2.380