Literature DB >> 27822754

Roles of leptin and ghrelin in the regulation of the phenotype and cytokine production by NK cells from peripheral blood.

S V Shirshev1, I V Nekrasova2, E G Orlova2, O L Gorbunova2.   

Abstract

Both leptin and ghrelin used separately at the concentrations corresponding to trimesters II-III of pregnancy increase the number of CD56bright NK cells in mononuclear cell suspension; their combination also enhances the L-selectin expression on the surface of these cells in the culture. These hormones do not affect the production of TGF-β1, IL-17А, or IFN-γ by NK cells, and they inhibit the production of IL-10. Leptin decreses the IL-4 production by NKp46+ cells, but the presence of ghrelin abrogates this effect.

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Year:  2016        PMID： 27822754     DOI： 10.1134/S0012496616050136

Source DB:  PubMed          Journal:  Dokl Biol Sci        ISSN： 0012-4966


  15 in total

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Authors:  A King; D S Allan; M Bowen; S J Powis; S Joseph; S Verma; S E Hiby; A J McMichael; Y W Loke; V M Braud
Journal:  Eur J Immunol       Date:  2000-06       Impact factor: 5.532

Review 2.  Natural killer cells and pregnancy.

Authors:  Ashley Moffett-King
Journal:  Nat Rev Immunol       Date:  2002-09       Impact factor: 53.106

Review 3.  Natural killer cells in pregnancy and recurrent pregnancy loss: endocrine and immunologic perspectives.

Authors:  Chrysoula Dosiou; Linda C Giudice
Journal:  Endocr Rev       Date:  2005-02       Impact factor: 19.871

4.  Interaction between energy homeostasis and reproduction: central effects of leptin and ghrelin on the reproductive axis.

Authors:  M Tena-Sempere
Journal:  Horm Metab Res       Date:  2013-10-23       Impact factor: 2.936

5.  Circulating leptin in women: a longitudinal study in the menstrual cycle and during pregnancy.

Authors:  L Hardie; P Trayhurn; D Abramovich; P Fowler
Journal:  Clin Endocrinol (Oxf)       Date:  1997-07       Impact factor: 3.478

6.  The role of pregnancy-associated hormones in regulation of expression of molecules responsible for NK cell functional activity.

Authors:  S V Shirshev; I V Nekrasova; S A Zamorina; O L Gorbunova; E G Orlova; I I Maslennikova
Journal:  Dokl Biol Sci       Date:  2014-08-30

7.  NK-active cytokines IL-2, IL-12, and IL-15 selectively modulate specific protein kinase C (PKC) isoforms in primary human NK cells.

Authors:  Marco Vitale; Alessandra Bassini; Paola Secchiero; Prisco Mirandola; Cristina Ponti; Loris Zamai; Adriana R Mariani; Mirella Falconi; Giacomo Azzali
Journal:  Anat Rec       Date:  2002-02-01

8.  Ghrelin and its relationship to growth hormones during normal pregnancy.

Authors:  Jens Fuglsang; Christian Skjaerbaek; Ulrick Espelund; Jan Frystyk; Sanne Fisker; Allan Flyvbjerg; Per Ovesen
Journal:  Clin Endocrinol (Oxf)       Date:  2005-05       Impact factor: 3.478

9.  TGFbeta promotes conversion of CD16+ peripheral blood NK cells into CD16- NK cells with similarities to decidual NK cells.

Authors:  Derin B Keskin; David S J Allan; Basya Rybalov; Milena M Andzelm; Joel N H Stern; Hernan D Kopcow; Louise A Koopman; Jack L Strominger
Journal:  Proc Natl Acad Sci U S A       Date:  2007-02-20       Impact factor: 11.205

10.  Mapping of NKp46(+) Cells in Healthy Human Lymphoid and Non-Lymphoid Tissues.

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Journal:  Front Immunol       Date:  2012-11-20       Impact factor: 7.561
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  3 in total

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Authors:  Ferdinando de Paula Silva; Cássia Mariana Bronzon da Costa; Luiz Miguel Pereira; Diego Fernando Silva Lessa; Dimitrius Leonardo Pitol; João Paulo Mardegan Issa; José Clóvis do Prado Júnior; Ana Amélia Carraro Abrahão
Journal:  Parasit Vectors       Date:  2019-11-09       Impact factor: 3.876

2.  Leptin stimulates tissue rat mast cell pro-inflammatory activity and migratory response.

Authors:  Paulina Żelechowska; Justyna Agier; Sylwia Różalska; Magdalena Wiktorska; Ewa Brzezińska-Błaszczyk
Journal:  Inflamm Res       Date:  2018-07-17       Impact factor: 4.575

3.  Ghrelin regulates sepsis‑induced rat acute gastric injury.

Authors:  Bin Li; Qingling Lin; Hong Guo; Liping Liu; Yumin Li
Journal:  Mol Med Rep       Date:  2019-04-30       Impact factor: 2.952
  3 in total

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