| Literature DB >> 27822752 |
S A Antonov1, E V Novosadova2, E L Arsenyeva2, M A Grefenstein2, A A Zykova2, A G Kobylyansky2, E S Manuilova2, I A Grivennikov2, S N Illarioshkin3, N F Myasoedov2.
Abstract
The influence of GABA receptor agonists on the terminal differentiation in vitro of dopaminergic (DA) neurons derived from IPS cells was investigated. GABA-A agonist muscimol induced transient elevation of intracellular Ca2+ level ([Ca2+] i ) in the investigated cells at days 5 to 21 of differentiation. Differentiation of cells in the presence of muscimol reduced tyrosine hydroxylase expression. Thus, the presence of active GABA-A receptors, associated with phenotype determination via Ca2+-signalling was demonstrated in differentiating human DA neurons.Entities:
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Year: 2016 PMID： 27822752 DOI： 10.1134/S0012496616050045
Source DB: PubMed Journal: Dokl Biol Sci ISSN： 0012-4966