Literature DB >> 27822425

NEAT1 regulates pancreatic cancer cell growth, invasion and migration though mircroRNA-335-5p/c-met axis.

Jia Cao1, Yi Zhang1, Jiachun Yang1, Sijia He1, Mingming Li1, Shiyan Yan1, Ying Chen1, Chunying Qu1, Leiming Xu1.   

Abstract

NEAT1 has been reported to affect cancer progression, which was subsequently confirmed in multiple cancers. Hsa-miRNA-335-5p (miR-335-5p) has recently been identified as an anticancer agent in various organs. However, the relationship between NEAT1 and miR-335-5p remains poorly understood. In this study, we investigated the effects of NEAT1 and miR-335-5p on development of pancreatic cancer. The ectopic expression of miR-335-5p in pancreatic cancer cell lines significantly suppressed cell growth by inhibiting c-met. In addition, downregulating NEAT1 upregulates miR-335-5p. Taken together, our results demonstrate that the NEAT1/miR-335-5p/c-met axis plays a pivotal role in pancreatic cancer by regulating the proliferation, metastasis, and apoptosis of pancreatic cancer cells in vivo and in vitro.

Entities:  

Keywords:  NEAT1; Pancreatic cancer; c-met; mircroRNA-335-5p

Year:  2016        PMID： 27822425      PMCID： PMC5088299     

Source DB:  PubMed          Journal:  Am J Cancer Res        ISSN： 2156-6976            Impact factor:   6.166


  44 in total

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2.  Altered expression of long non-coding RNAs during genotoxic stress-induced cell death in human glioma cells.

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Review 4.  Clinical significance of MET in gastric cancer.

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Review 5.  Developing c-MET pathway inhibitors for cancer therapy: progress and challenges.

Authors:  Xiangdong Liu; Robert C Newton; Peggy A Scherle
Journal:  Trends Mol Med       Date:  2009-12-22       Impact factor: 11.951

6.  MET in gastric carcinomas: comparison between protein expression and gene copy number and impact on clinical outcome.

Authors:  H E Lee; M A Kim; H S Lee; E-J Jung; H-K Yang; B L Lee; Y-J Bang; W H Kim
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7.  Identification of hsa-miR-335 as a prognostic signature in gastric cancer.

Authors:  Zhi Yan; Yimin Xiong; Weitian Xu; Juan Gao; Yi Cheng; Zhigang Wang; Fang Chen; Guorong Zheng
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8.  Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via the mTORC1/FASN pathway in mice.

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Review 9.  Long non-coding RNA: a new player in cancer.

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  25 in total

1.  Long non-coding RNA NEAT1/miR-193a-3p regulates LPS-induced apoptosis and inflammatory injury in WI-38 cells through TLR4/NF-κB signaling.

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Journal:  Am J Transl Res       Date:  2019-09-15       Impact factor: 4.060

2.  Long non-coding RNA nuclear paraspeckle assembly transcript 1 promotes activation of T helper 2 cells via inhibiting STAT6 ubiquitination.

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Review 3.  Research updates on the clinical implication of long noncoding RNA in digestive system cancers and chemoresistance.

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4.  BAP1 dependent expression of long non-coding RNA NEAT-1 contributes to sensitivity to gemcitabine in cholangiocarcinoma.

Authors:  Mansi Parasramka; Irene K Yan; Xue Wang; Phuong Nguyen; Akiko Matsuda; Sayantan Maji; Catherine Foye; Yan Asmann; Tushar Patel
Journal:  Mol Cancer       Date:  2017-01-25       Impact factor: 27.401

5.  Long non-coding RNA TUG1 promotes migration and invasion by acting as a ceRNA of miR-335-5p in osteosarcoma cells.

Authors:  Yong Wang; Tao Yang; Zhen Zhang; Ming Lu; Wei Zhao; Xiandong Zeng; Weiguo Zhang
Journal:  Cancer Sci       Date:  2017-05-19       Impact factor: 6.716

6.  CPNE1 is a target of miR-335-5p and plays an important role in the pathogenesis of non-small cell lung cancer.

Authors:  Haicheng Tang; Jianjie Zhu; Wenwen Du; Shunlin Liu; Yuanyuan Zeng; Zongli Ding; Yang Zhang; Xueting Wang; Zeyi Liu; Jianan Huang
Journal:  J Exp Clin Cancer Res       Date:  2018-07-03

Review 7.  The Role of Long Non-Coding RNAs in Thyroid Cancer.

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8.  The Functional Characterization of Epigenetically Related lncRNAs Involved in Dysregulated CeRNA-CeRNA Networks Across Eight Cancer Types.

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9.  Long non-coding RNA NEAT1-modulated abnormal lipolysis via ATGL drives hepatocellular carcinoma proliferation.

Authors:  Xirui Liu; Yingjian Liang; Ruipeng Song; Guangchao Yang; Jihua Han; Yaliang Lan; Shangha Pan; Mingxi Zhu; Yao Liu; Yan Wang; Fanzheng Meng; Yifeng Cui; Jiabei Wang; Bo Zhang; Xuan Song; Zhaoyang Lu; Tongsen Zheng; Lianxin Liu
Journal:  Mol Cancer       Date:  2018-05-15       Impact factor: 27.401

10.  The long non-coding RNA NEAT1 enhances epithelial-to-mesenchymal transition and chemoresistance via the miR-34a/c-Met axis in renal cell carcinoma.

Authors:  Fei Liu; Na Chen; Yanchun Gong; Ruihai Xiao; Weichao Wang; Zhengyue Pan
Journal:  Oncotarget       Date:  2017-05-10
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