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Literature DB >> 27822001

Osteomyelitis: Recent advances in pathophysiology and therapeutic strategies.

Mitchell C Birt¹, David W Anderson¹, E Bruce Toby¹, Jinxi Wang¹.

Abstract

This review article summarizes the recent advances in pathogenic mechanisms and novel therapeutic strategies for osteomyelitis, covering both periprosthetic joint infections and fracture-associated bone infections. A better understanding of the pathophysiology including the mechanisms for biofilm formation has led to new therapeutic strategies for this devastating disease. Research on novel local delivery materials with appropriate mechanical properties, lower exothermicity, controlled release of antibiotics, and absorbable scaffolding for bone regeneration is progressing rapidly. Emerging strategies for prevention, early diagnosis of low-grade infections, and innovative treatments of osteomyelitis such as biofilm disruptors and immunotherapy are highlighted in this review.

Entities: Disease

Keywords: Antibiotic; Arthroplasty; Bone infection; Fracture; Osteomyelitis

Year: 2016 PMID： 27822001 PMCID： PMC5090239 DOI： 10.1016/j.jor.2016.10.004

Source DB: PubMed Journal: J Orthop ISSN： 0972-978X

97 in total

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Journal: Clin Orthop Relat Res Date: 2004-10 Impact factor: 4.176

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Authors: Mohamed N Rahaman; B Sonny Bal; Wenhai Huang
Journal: Mater Sci Eng C Mater Biol Appl Date: 2014-05-02 Impact factor: 7.328

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Journal: Clin Orthop Relat Res Date: 2005-08 Impact factor: 4.176

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Authors: Alex C McLaren
Journal: Clin Orthop Relat Res Date: 2004-10 Impact factor: 4.176

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Journal: Br J Anaesth Date: 2009-01 Impact factor: 9.166

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Journal: J Trauma Date: 1998-10

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Journal: J Mater Sci Mater Med Date: 2015-09-28 Impact factor: 3.896

8. Prolonged bacterial culture to identify late periprosthetic joint infection: a promising strategy.

Authors: Peter Schäfer; Bernd Fink; Dieter Sandow; Andreas Margull; Irina Berger; Lars Frommelt
Journal: Clin Infect Dis Date: 2008-12-01 Impact factor: 9.079

9. First Clinical Experience With Thermal-Sprayed Silver Oxide-Containing Hydroxyapatite Coating Implant.

Authors: Shuichi Eto; Shunsuke Kawano; Shinsuke Someya; Hiroshi Miyamoto; Motoki Sonohata; Masaaki Mawatari
Journal: J Arthroplasty Date: 2015-12-23 Impact factor: 4.757

10. Novel inhibitors of Staphylococcus aureus virulence gene expression and biofilm formation.

Authors: Yibao Ma; Yuanxi Xu; Bryan D Yestrepsky; Roderick J Sorenson; Meng Chen; Scott D Larsen; Hongmin Sun
Journal: PLoS One Date: 2012-10-15 Impact factor: 3.240

43 in total

1. Deriving a dose and regimen for anti-glucosaminidase antibody passive-immunisation for patients with Staphylococcus aureus osteomyelitis.

Authors: C C Lee; R D Southgate; C Jiao; E Gersz; J R Owen; S L Kates; C A Beck; C Xie; J L Daiss; V Post; T F Moriarty; S Zeiter; E M Schwarz; G Muthukrishnan
Journal: Eur Cell Mater Date: 2020-01-31 Impact factor: 3.942

2. Obesity/type 2 diabetes increases inflammation, periosteal reactive bone formation, and osteolysis during Staphylococcus aureus implant-associated bone infection.

Authors: Christopher W Farnsworth; Eric M Schott; Abigail M Benvie; Jacob Zukoski; Stephen L Kates; Edward M Schwarz; Steven R Gill; Michael J Zuscik; Robert A Mooney
Journal: J Orthop Res Date: 2018-01-03 Impact factor: 3.494

3. Exebacase in Addition to Daptomycin Is More Active than Daptomycin or Exebacase Alone in Methicillin-Resistant Staphylococcus aureus Osteomyelitis in Rats.

Authors: Melissa J Karau; Suzannah M Schmidt-Malan; Qun Yan; Kerryl E Greenwood-Quaintance; Jayawant Mandrekar; Dario Lehoux; Raymond Schuch; Cara Cassino; Robin Patel
Journal: Antimicrob Agents Chemother Date: 2019-09-23 Impact factor: 5.191

4. Antimicrobial peptide in polymethylmethacrylate bone cement as a prophylaxis of infectious complications in orthopedics-an experiment in a murine model.

Authors: Pavel Melicherčík; Karel Kotaška; David Jahoda; Ivan Landor; Václav Čeřovský
Journal: Folia Microbiol (Praha) Date: 2022-05-25 Impact factor: 2.629

10. Lack of Humoral Immunity Against Glucosaminidase Is Associated with Postoperative Complications in Staphylococcus aureus Osteomyelitis.

Authors: Stephen L Kates; John R Owen; Christopher A Beck; Chao Xie; Gowrishankar Muthukrishnan; John L Daiss; Edward M Schwarz
Journal: J Bone Joint Surg Am Date: 2020-11-04 Impact factor: 6.558