| Literature DB >> 27821455 |
Dachuan Lin1,2, Miaomiao Xie1,2, Ruichao Li1,2, Kaichao Chen1,2, Edward Wai-Chi Chan2, Sheng Chen3,2.
Abstract
This study aims to investigate the prevalence and transmission dynamics of the blaNDM-1 gene in animal Escherichia coli strains. Two IncFII blaNDM-1-encoding plasmids with only minor structural variation in the MDR region, pHNEC46-NDM and pHNEC55-NDM, were found to be responsible for the transmission of blaNDM-1 in these strains. The blaNDM-1 gene can be incorporated into plasmids and stably inherited in animal-borne E. coli strains that can be maintained in animal gut microflora even without carbapenem selection pressure.Entities:
Keywords: Escherichia coli; IncFII; animal; blaNDM-1; plasmid sequence; transposons
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Year: 2016 PMID: 27821455 PMCID: PMC5192157 DOI: 10.1128/AAC.02285-16
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191