Literature DB >> 27821455

IncFII Conjugative Plasmid-Mediated Transmission of blaNDM-1 Elements among Animal-Borne Escherichia coli Strains.

Dachuan Lin1,2, Miaomiao Xie1,2, Ruichao Li1,2, Kaichao Chen1,2, Edward Wai-Chi Chan2, Sheng Chen3,2.   

Abstract

This study aims to investigate the prevalence and transmission dynamics of the blaNDM-1 gene in animal Escherichia coli strains. Two IncFII blaNDM-1-encoding plasmids with only minor structural variation in the MDR region, pHNEC46-NDM and pHNEC55-NDM, were found to be responsible for the transmission of blaNDM-1 in these strains. The blaNDM-1 gene can be incorporated into plasmids and stably inherited in animal-borne E. coli strains that can be maintained in animal gut microflora even without carbapenem selection pressure.
Copyright © 2016 American Society for Microbiology.

Entities:  

Keywords:  Escherichia coli; IncFII; animal; blaNDM-1; plasmid sequence; transposons

Mesh:

Substances:

Year:  2016        PMID: 27821455      PMCID: PMC5192157          DOI: 10.1128/AAC.02285-16

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN: 0066-4804            Impact factor:   5.191


  20 in total

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