Literature DB >> 27821441

β-Lactamase Inhibitors Enhance the Synergy between β-Lactam Antibiotics and Daptomycin against Methicillin-Resistant Staphylococcus aureus.

Karl Evans R Henson1, Juwon Yim2, Jordan R Smith2, George Sakoulas3, Michael J Rybak4,5.   

Abstract

The evidence for using combination therapy for the treatment of serious methicillin-resistant Staphylococcus aureus (MRSA) infections is growing. In this study, we investigated the synergistic effect of daptomycin (DAP) combined with piperacillin-tazobactam and ampicillin-sulbactam against MRSA in time-kill experiments. Six of eight strains demonstrated synergy between DAP and the β-lactam-β-lactamase inhibitor (BLI) combination. In 5/8 strains, the synergy occurred only in the presence of the BLI, highlighting a role for BLIs in peptide-β-lactam synergy.
Copyright © 2016 American Society for Microbiology.

Entities:  

Keywords:  antibiotic combination; synergy; β-lactamase inhibitor; β-lactams

Mesh：

Substances：

Year:  2016        PMID： 27821441      PMCID： PMC5192128          DOI： 10.1128/AAC.01564-16

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

1.  Novel daptomycin combinations against daptomycin-nonsusceptible methicillin-resistant Staphylococcus aureus in an in vitro model of simulated endocardial vegetations.

Authors:  Molly E Steed; Celine Vidaillac; Michael J Rybak
Journal:  Antimicrob Agents Chemother       Date:  2010-10-04       Impact factor: 5.191

2.  Comparison of three different in vitro methods of detecting synergy: time-kill, checkerboard, and E test.

Authors:  R L White; D S Burgess; M Manduru; J A Bosso
Journal:  Antimicrob Agents Chemother       Date:  1996-08       Impact factor: 5.191

3.  Evidence for a dual role of PBP1 in the cell division and cell separation of Staphylococcus aureus.

Authors:  Sandro F F Pereira; Adriano O Henriques; Mariana G Pinho; Herminia de Lencastre; Alexander Tomasz
Journal:  Mol Microbiol       Date:  2009-04-27       Impact factor: 3.501

4.  Daptomycin in Combination with Ceftolozane-Tazobactam or Cefazolin against Daptomycin-Susceptible and -Nonsusceptible Staphylococcus aureus in an In Vitro, Hollow-Fiber Model.

Authors:  Jordan R Smith; Anu Arya; Juwon Yim; Katie E Barber; Jessica Hallesy; Nivedita B Singh; Michael J Rybak
Journal:  Antimicrob Agents Chemother       Date:  2016-06-20       Impact factor: 5.191

5.  Evaluation of daptomycin pharmacodynamics and resistance at various dosage regimens against Staphylococcus aureus isolates with reduced susceptibilities to daptomycin in an in vitro pharmacodynamic model with simulated endocardial vegetations.

Authors:  Warren E Rose; Steven N Leonard; Michael J Rybak
Journal:  Antimicrob Agents Chemother       Date:  2008-06-30       Impact factor: 5.191

6.  Antimicrobial salvage therapy for persistent staphylococcal bacteremia using daptomycin plus ceftaroline.

Authors:  George Sakoulas; Pamela A Moise; Anthony M Casapao; Poochit Nonejuie; Joshua Olson; Cheryl Y M Okumura; Michael J Rybak; Ravina Kullar; Abhay Dhand; Warren E Rose; Debra A Goff; Adam M Bressler; Yuman Lee; Joseph Pogliano; Scott Johns; Glenn W Kaatz; John R Ebright; Victor Nizet
Journal:  Clin Ther       Date:  2014-07-10       Impact factor: 3.393

7.  β-Lactam antibiotics targeting PBP1 selectively enhance daptomycin activity against methicillin-resistant Staphylococcus aureus.

Authors:  Andrew D Berti; George Sakoulas; Victor Nizet; Ryan Tewhey; Warren E Rose
Journal:  Antimicrob Agents Chemother       Date:  2013-07-29       Impact factor: 5.191

8.  Addition of ceftaroline to daptomycin after emergence of daptomycin-nonsusceptible Staphylococcus aureus during therapy improves antibacterial activity.

Authors:  Warren E Rose; Lucas T Schulz; David Andes; Rob Striker; Andrew D Berti; Paul R Hutson; Sanjay K Shukla
Journal:  Antimicrob Agents Chemother       Date:  2012-08-06       Impact factor: 5.191

9.  The combination of ceftaroline plus daptomycin allows for therapeutic de-escalation and daptomycin sparing against MRSA.

Authors:  Katie E Barber; Brian J Werth; Michael J Rybak
Journal:  J Antimicrob Chemother       Date:  2014-09-22       Impact factor: 5.790

10.  Penicillin Binding Protein 1 Is Important in the Compensatory Response of Staphylococcus aureus to Daptomycin-Induced Membrane Damage and Is a Potential Target for β-Lactam-Daptomycin Synergy.

Authors:  Andrew D Berti; Erin Theisen; John-Demian Sauer; Poochit Nonejuie; Joshua Olson; Joseph Pogliano; George Sakoulas; Victor Nizet; Richard A Proctor; Warren E Rose
Journal:  Antimicrob Agents Chemother       Date:  2015-11-02       Impact factor: 5.191
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  3 in total

1.  Combination of Tedizolid and Daptomycin against Methicillin-Resistant Staphylococcus aureus in an In Vitro Model of Simulated Endocardial Vegetations.

Authors:  Jordan R Smith; Juwon Yim; Seth Rice; Kyle Stamper; Razie Kebriaei; Michael J Rybak
Journal:  Antimicrob Agents Chemother       Date:  2018-04-26       Impact factor: 5.191

Review 2.  Targeting the Holy Triangle of Quorum Sensing, Biofilm Formation, and Antibiotic Resistance in Pathogenic Bacteria.

Authors:  Ronit Vogt Sionov; Doron Steinberg
Journal:  Microorganisms       Date:  2022-06-16

3.  Synergistic Anti-MRSA Activity of Cationic Nanostructured Lipid Carriers in Combination With Oxacillin for Cutaneous Application.

Authors:  Ahmed Alalaiwe; Pei-Wen Wang; Po-Liang Lu; Ya-Ping Chen; Jia-You Fang; Shih-Chun Yang
Journal:  Front Microbiol       Date:  2018-07-04       Impact factor: 5.640
  3 in total

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