Literature DB >> 27819109

A Journey in Science: "Not Lost in Translation".

Tak Mak1.   

Abstract

Real innovations in medicine and science are historic and singular; the stories behind each occurrence are precious. At Molecular Medicine we have established the Anthony Cerami Award in Translational Medicine to document and preserve these histories. The monographs recount the seminal events as told in the voice of the original investigators who provided the crucial early insight. These essays capture the essence of discovery, chronicling the birth of ideas that created new fields of research; and launched trajectories that persisted and ultimately influenced how disease is prevented, diagnosed, and treated. In this volume, the Cerami Award Monograph is by Tak Mak, PhD, Professor, The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Princess Margaret Cancer Centre in Toronto. A visionary in the field of cancer, this is the story of Dr. Mak's scientific journey.

Entities:  

Keywords:  cancer; cell death; genetics; immunology; tumorigenesis

Year:  2016        PMID: 27819109      PMCID: PMC5135081          DOI: 10.2119/molmed.2016.00176

Source DB:  PubMed          Journal:  Mol Med        ISSN: 1076-1551            Impact factor:   6.354


  25 in total

1.  The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway.

Authors:  Min Fang; Zhirong Shen; Song Huang; Liping Zhao; She Chen; Tak W Mak; Xiaodong Wang
Journal:  Cell       Date:  2010-11-11       Impact factor: 41.582

2.  Profound block in thymocyte development in mice lacking p56lck.

Authors:  T J Molina; K Kishihara; D P Siderovski; W van Ewijk; A Narendran; E Timms; A Wakeham; C J Paige; K U Hartmann; A Veillette
Journal:  Nature       Date:  1992-05-14       Impact factor: 49.962

3.  The Friend spleen focus-forming virus (SFFV) genome: fractionation and analysis of SFFV and helper virus-related sequences.

Authors:  T W Mak; D Penrose; C Gamble; A Bernstein
Journal:  Virology       Date:  1978-06-01       Impact factor: 3.616

4.  CD8 is needed for development of cytotoxic T cells but not helper T cells.

Authors:  W P Fung-Leung; M W Schilham; A Rahemtulla; T M Kündig; M Vollenweider; J Potter; W van Ewijk; T W Mak
Journal:  Cell       Date:  1991-05-03       Impact factor: 41.582

5.  A third type of murine T-cell receptor gene.

Authors:  Y Chien; D M Becker; T Lindsten; M Okamura; D I Cohen; M M Davis
Journal:  Nature       Date:  1984 Nov 1-7       Impact factor: 49.962

6.  The T-lymphocyte antigen receptor--elusive no more.

Authors:  A F Williams
Journal:  Nature       Date:  1984 Mar 8-14       Impact factor: 49.962

7.  DJ-1, a novel regulator of the tumor suppressor PTEN.

Authors:  Raymond H Kim; Malte Peters; YingJu Jang; Wei Shi; Melania Pintilie; Graham C Fletcher; Carmela DeLuca; Jennifer Liepa; Lily Zhou; Bryan Snow; Richard C Binari; Armen S Manoukian; Mark R Bray; Fei-Fei Liu; Ming-Sound Tsao; Tak W Mak
Journal:  Cancer Cell       Date:  2005-03       Impact factor: 31.743

8.  Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment.

Authors:  M D Pegram; A Lipton; D F Hayes; B L Weber; J M Baselga; D Tripathy; D Baly; S A Baughman; T Twaddell; J A Glaspy; D J Slamon
Journal:  J Clin Oncol       Date:  1998-08       Impact factor: 44.544

9.  A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains.

Authors:  Y Yanagi; Y Yoshikai; K Leggett; S P Clark; I Aleksander; T W Mak
Journal:  Nature       Date:  1984 Mar 8-14       Impact factor: 49.962

10.  Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4.

Authors:  P Waterhouse; J M Penninger; E Timms; A Wakeham; A Shahinian; K P Lee; C B Thompson; H Griesser; T W Mak
Journal:  Science       Date:  1995-11-10       Impact factor: 47.728

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