Literature DB >> 2781856

Poly(butyl-2-cyanoacrylate) particles as adjuvants for oral immunization.

D T O'Hagan1, K J Palin, S S Davis.   

Abstract

The potential oral adjuvanticity of a colloidal carrier system for an adsorbed antigen was investigated and the effect of particle size of the carrier was partially determined. Ovalbumin was adsorbed onto poly(butyl-2-cyanoacrylate) particles of two different sizes and administered orally to rats previously primed by intraperitoneal injection. After 14 and 50 days, the secretory immune responses were significantly increased for animals gastrically intubated with ovalbumin adsorbed to 100 nm particles, relative to a control group response to soluble antigen.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2781856     DOI： 10.1016/0264-410x(89)90231-4

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  5 in total

Review 1.  The intestinal uptake of particles and the implications for drug and antigen delivery.

Authors:  D T O'Hagan
Journal:  J Anat       Date:  1996-12       Impact factor: 2.610

2.  Intestinal absorption of PLAGA microspheres in the rat.

Authors:  C Damgé; M Aprahamian; H Marchais; J P Benoit; M Pinget
Journal:  J Anat       Date:  1996-12       Impact factor: 2.610

3.  Formulation and evaluation of oral microparticulate ovarian cancer vaccines.

Authors:  Suprita A Tawde; Lipika Chablani; Archana Akalkotkar; Cherilyn D'Souza; Maurizio Chiriva-Internati; Periasamy Selvaraj; Martin J D'Souza
Journal:  Vaccine       Date:  2012-06-28       Impact factor: 3.641

4.  Orally administered microencapsulated Bordetella pertussis fimbriae protect mice from B. pertussis respiratory infection.

Authors:  D H Jones; B W McBride; C Thornton; D T O'Hagan; A Robinson; G H Farrar
Journal:  Infect Immun       Date:  1996-02       Impact factor: 3.441

Review 5.  Demystifying particle-based oral vaccines.

Authors:  Pedro Gonzalez-Cruz; Harvinder Singh Gill
Journal:  Expert Opin Drug Deliv       Date:  2021-07-06       Impact factor: 8.129
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.