| Literature DB >> 2781855 |
Abstract
Infectious diarrhoea is one leading cause of infantile mortality in developing countries. Rotaviruses and other enteroviruses have an important role in diarrhoea but, currently, there are no vaccines available to immunize infants. The use of oral poliovirus vaccine (OPV) over two decades has shown that, besides protecting effectively against poliomyelitis, it can interfere with intestinal infection by other enteroviruses. This interference by the vaccine viruses could explain two epidemiological observations showing that repeated and massive administration of OPV was followed by a statistically significant decrease of infantile diarrhoea mortality. OPV administration could have two objectives: to prevent poliomyelitis and to reduce infantile diarrhoea of viral aetiology.Entities:
Keywords: Americas; Biology; Brazil; Child Health Services; Chile; Delivery Of Health Care; Demographic Factors; Developing Countries; Diarrhea; Diarrhea, Infantile; Diseases; Gastrointestinal Effects; Health; Health Services; Immunization; Infant Mortality--changes; Infections; Integrated Programs; Latin America; Maternal-child Health Services; Mortality; Organization And Administration; Physiology; Population; Population Dynamics; Primary Health Care; Programs; South America; Vaccination; Viral Diseases
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Year: 1989 PMID： 2781855 DOI： 10.1016/0264-410x(89)90230-2
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641