Disposition and dosage regimen of cephaloridine in calves.

The disposition and dosage regimen of cephaloridine were investigated in healthy calves following a single intramuscular administration of 10 mg/kg. The absorption halflife, elimination halflife, apparent volume of distribution and total body clearance were 0.107 +/- 0.025 h, 2.08 +/- 0.14 h, 0.70 +/- 0.07 L kg-1 and 235.8 +/- 21.9 ml kg-1 h-1, respectively. Therapeutic plasma levels (greater than or equal to 1 micrograms/ml) were maintained for up to 7 h. A satisfactory intramuscular dosage regimen for cephaloridine in calves would be 10 mg/kg repeated at 8 h intervals.