Yan Sheng1, Guangxiu Lu2, Jiayin Liu3, Xiaoyan Liang4, Yanping Ma5, Xuehong Zhang6, Songying Zhang7, Yingpu Sun8, Yun Sun9, Wenfeng Chen10, Wenhui Fang10, Zijiang Chen11. 1. Center for Reproductive Medicine, Shandong University, Jinan, China. 2. Reproductive & Genetic Hospital CITIC-Xiangya, Changsha, China. 3. Jiangsu Province Hospital, Nanjing, China. 4. The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China. 5. The First People's Hospital of Yunnan Province, Kunming, China. 6. The First Hospital of Lanzhou University, Lanzhou, China. 7. Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China. 8. The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. 9. Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. 10. Merck Serono Co., Ltd, Beijing, China. 11. Center for Reproductive Medicine, Shandong University, Jinan, China. chenzijiang@hotmail.com.
Abstract
PURPOSE: The purpose of the present study is to explore the influence of body mass index (BMI) on outcomes of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) techniques in Chinese women with polycystic ovary syndrome (PCOS). METHODS: This was a multicenter, prospective, observational study that enrolled 800 subjects with PCOS from nine hospitals in China. Patients were categorized according to BMI categories: underweight, <18.5 kg/m2; normal, 19-23.9 kg/m2; overweight, 24-27.9 kg/m2; and obese, ≥28 kg/m2. Total recombinant follicle-stimulating hormone (rFSH) dose used, estradiol, and progesterone levels on human chorionic gonadotropin (hCG) day; implantation rate; and biochemical, clinical, and ongoing pregnancy rates were compared among BMI categories. Hormone levels (estradiol, follicle-stimulating hormone (FSH), LH, testosterone, and progesterone) were measured using electrochemiluminescence assays. RESULTS: Among the 774 subjects, 27.3 % were overweight and 8.1 % were obese. The rFSH dose used differed significantly among BMI categories (P < 0.001). The implantation rate was lower in obese subjects than that in normal-weight subjects (25.3 vs 45.7 %). Clinical pregnancy rate per transfer differed among BMI categories (P = 0.033), but there was no difference for biochemical (P = 0.327) and ongoing (P = 0.084) pregnancy rates. The miscarriage rate was similar among BMI categories. CONCLUSIONS: More than one third of Chinese women with PCOS undergoing IVF/ICSI are overweight or obese. Elevated BMI is associated with reduced clinical pregnancy rate but similar ongoing pregnancy rates, suggesting that BMI has little impact on IVF outcomes.
PURPOSE: The purpose of the present study is to explore the influence of body mass index (BMI) on outcomes of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) techniques in Chinese women with polycystic ovary syndrome (PCOS). METHODS: This was a multicenter, prospective, observational study that enrolled 800 subjects with PCOS from nine hospitals in China. Patients were categorized according to BMI categories: underweight, <18.5 kg/m2; normal, 19-23.9 kg/m2; overweight, 24-27.9 kg/m2; and obese, ≥28 kg/m2. Total recombinant follicle-stimulating hormone (rFSH) dose used, estradiol, and progesterone levels on humanchorionic gonadotropin (hCG) day; implantation rate; and biochemical, clinical, and ongoing pregnancy rates were compared among BMI categories. Hormone levels (estradiol, follicle-stimulating hormone (FSH), LH, testosterone, and progesterone) were measured using electrochemiluminescence assays. RESULTS: Among the 774 subjects, 27.3 % were overweight and 8.1 % were obese. The rFSH dose used differed significantly among BMI categories (P < 0.001). The implantation rate was lower in obese subjects than that in normal-weight subjects (25.3 vs 45.7 %). Clinical pregnancy rate per transfer differed among BMI categories (P = 0.033), but there was no difference for biochemical (P = 0.327) and ongoing (P = 0.084) pregnancy rates. The miscarriage rate was similar among BMI categories. CONCLUSIONS: More than one third of Chinese women with PCOS undergoing IVF/ICSI are overweight or obese. Elevated BMI is associated with reduced clinical pregnancy rate but similar ongoing pregnancy rates, suggesting that BMI has little impact on IVF outcomes.
Entities:
Keywords:
Body mass index; In vitro fertilization; Intracytoplasmic sperm injections; Polycystic ovary syndrome; Pregnancy rate
Authors: Janet W Rich-Edwards; Donna Spiegelman; Miriam Garland; Ellen Hertzmark; David J Hunter; Graham A Colditz; Walter C Willett; Handan Wand; JoAnn E Manson Journal: Epidemiology Date: 2002-03 Impact factor: 4.822
Authors: Divya K Shah; Stacey A Missmer; Katharine F Berry; Catherine Racowsky; Elizabeth S Ginsburg Journal: Obstet Gynecol Date: 2011-07 Impact factor: 7.661
Authors: Karen C Schliep; Sunni L Mumford; Katherine A Ahrens; James M Hotaling; Douglas T Carrell; Megan Link; Stefanie N Hinkle; Kerri Kissell; Christina A Porucznik; Ahmad O Hammoud Journal: Fertil Steril Date: 2014-12-10 Impact factor: 7.329
Authors: Esther C A M van Swieten; Loes van der Leeuw-Harmsen; Erik A Badings; Paul J Q van der Linden Journal: Gynecol Obstet Invest Date: 2005-03-07 Impact factor: 2.031