| Literature DB >> 27817028 |
E V Kuevda1, E A Gubareva2, S V Krasheninnikov3, T E Grigoriev3, I S Gumenyuk2, A S Sotnichenko2, I V Gilevich2, D D Karal-Ogly4, S V Orlov4, S N Chvalun3, A N Redko2, S N Alekseenko2, P Macciarini2.
Abstract
The effect of decellularization on the biomechanical properties of macaque lungs was studied. The quality of the biological scaffold was additionally assessed by morphological methods, and the contents of extracellular matrix (ECM) fibers were determined both qualitatively and quantitatively. Histological analysis revealed no damage of structural integrity of ECM components, but the scaffold elasticity significantly decreased, which was confirmed by the changes in the hysteresis loop without a concomitant decrease in peak loads, with the mechanical strength of the samples being retained. These changes require taking additional measures to prevent a decrease in the effective lung volume.Mesh：
Year: 2016 PMID： 27817028 DOI： 10.1134/S1607672916050203
Source DB: PubMed Journal: Dokl Biochem Biophys ISSN： 1607-6729 Impact factor: 0.788