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Literature DB >> 27817017

The effect of pregnancy-specific β1-glycoprotein 1 on the transcription factor FOXP3 expression by immunocompetent cells.

S A Zamorina¹, L S Litvinova², K A Yurova², N A Dunets², O G Khaziakhmatova², V P Timganova¹, M S Bochkova¹, P V Khramtsov¹, M B Rayev^3,4.

Abstract

The role of human pregnancy-specific β1-glycoprotein (PSG) in the regulation of expression of the transcription factor FOXP3 was studied. It is found that, under conditions of directed induction of phenotypic changes in CD4+ lymphocytes to regulatory T cells (Treg), PSG at high concentrations (10 and 100 μg/mL) increased FOXP3 expression. The evaluation of the spontaneous expression level of FOXP3 mRNA showed that PSG (1 and 100 μg/mL) stimulated the expression of this factor in mononuclear cells and isolated CD4+ lymphocytes. Thus, PSG stimulates FOXP3 expression in immunocompetent cells.

Entities: Gene Species

Mesh：

Substances：

Year: 2016 PMID： 27817017 DOI： 10.1134/S1607672916050161

Source DB: PubMed Journal: Dokl Biochem Biophys ISSN： 1607-6729 Impact factor: 0.788

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Review 4. Pregnancy-specific glycoproteins: complex gene families regulating maternal-fetal interactions.

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5. Binding of pregnancy-specific glycoprotein 17 to CD9 on macrophages induces secretion of IL-10, IL-6, PGE2, and TGF-beta1.

Authors: Cam T Ha; Roseann Waterhouse; Jennifer Wessells; Julie A Wu; Gabriela S Dveksler
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Authors: Kyle Malone; Jennifer A Shearer; John M Williams; Anne C Moore; Tom Moore; Christian Waeber
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1 in total

The effect of pregnancy-specific β1-glycoprotein 1 on the transcription factor FOXP3 expression by immunocompetent cells.

1. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

Review 2. Involvement of JAK/STAT signaling in the pathogenesis of inflammatory bowel disease.

Review 3. The role of pregnancy-specific glycoprotein 1a (PSG1a) in regulating the innate and adaptive immune response.

Review 4. Pregnancy-specific glycoproteins: complex gene families regulating maternal-fetal interactions.

5. Binding of pregnancy-specific glycoprotein 17 to CD9 on macrophages induces secretion of IL-10, IL-6, PGE2, and TGF-beta1.

6. Coevolution of activating and inhibitory receptors within mammalian carcinoembryonic antigen families.

Review 7. The immunology of pregnancy: regulatory T cells control maternal immune tolerance toward the fetus.

Review 8. Regulatory T cells: how do they suppress immune responses?

Review 9. Immune privilege induced by regulatory T cells in transplantation tolerance.

Review 10. Regulatory T-cells in pregnancy: historical perspective, state of the art, and burning questions.

1. Recombinant pregnancy-specific glycoprotein-1-Fc reduces functional deficit in a mouse model of permanent brain ischaemia.