Literature DB >> 27817015

Antitumor efficacy of combined gene and radiotherapy in animals.

O A Bezborodova1, E R Nemtsova2, A R Gevorkov2, A V Boyko2, J B Venediktova2, I V Alekseenko3,4, M B Kostina4, G S Monastyrskaya4, E D Sverdlov3,4, E V Khmelevskiy2, R I Yakubovskaya2.   

Abstract

Antitumor efficacy of the combined suicide gene therapy and radiotherapy was studied on the model of CT26 murine colon adenocarcinoma. CMV-FCU1-IRES-mGM-CSF-pGL3 construct with PEG-PEI-TAT (FCU1-mGM/5-FC) block copolymer as a vector was used for intratumoral administration. Tumors were irradiated with a single 5 Gy dose. The efficacy was evaluated according to the grade of tumor growth inhibition (T/C) and lifespan of the animals. Pronounced antitumor activity of the combined use of FCU1-mGM/5-FC system with radiotherapy on the background of prolonged lifespan and the synergism of the applied methods was revealed.

Entities:  

Mesh：

Substances：

Year:  2016        PMID： 27817015     DOI： 10.1134/S1607672916050112

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  10 in total

Review 1.  New and emerging radiosensitizers and radioprotectors.

Authors:  Aaron C Spalding; Theodore S Lawrence
Journal:  Cancer Invest       Date:  2006 Jun-Jul       Impact factor: 2.176

Review 2.  Enzymes to die for: exploiting nucleotide metabolizing enzymes for cancer gene therapy.

Authors:  Andressa Ardiani; Adam J Johnson; Hongmei Ruan; Marilyn Sanchez-Bonilla; Kinta Serve; Margaret E Black
Journal:  Curr Gene Ther       Date:  2012-04-01       Impact factor: 4.391

Review 3.  Issues in experimental design and endpoint analysis in the study of experimental cytotoxic agents in vivo in breast cancer and other models.

Authors:  R Clarke
Journal:  Breast Cancer Res Treat       Date:  1997 Nov-Dec       Impact factor: 4.872

4.  In vivo cancer gene therapy by adenovirus-mediated transfer of a bifunctional yeast cytosine deaminase/uracil phosphoribosyltransferase fusion gene.

Authors:  P Erbs; E Regulier; J Kintz; P Leroy; Y Poitevin; F Exinger; R Jund; M Mehtali
Journal:  Cancer Res       Date:  2000-07-15       Impact factor: 12.701

Review 5.  Genetic surgery - a right strategy to attack cancer.

Authors:  Eugene D Sverdlov
Journal:  Curr Gene Ther       Date:  2011-12       Impact factor: 4.391

Review 6.  Antimetabolite radiosensitizers.

Authors:  Donna S Shewach; Theodore S Lawrence
Journal:  J Clin Oncol       Date:  2007-09-10       Impact factor: 44.544

7.  Suicide gene and cytokines combined nonviral gene therapy for spontaneous canine melanoma.

Authors:  L M E Finocchiaro; G L Fiszman; A L Karara; G C Glikin
Journal:  Cancer Gene Ther       Date:  2008-01-25       Impact factor: 5.987

8.  Replication-competent adenovirus-mediated suicide gene therapy with radiation in a preclinical model of pancreatic cancer.

Authors:  Svend O Freytag; Kenneth N Barton; Stephen L Brown; Vinod Narra; Yingshu Zhang; Don Tyson; Colleen Nall; Mei Lu; Munther Ajlouni; Benjamin Movsas; Jae Ho Kim
Journal:  Mol Ther       Date:  2007-06-12       Impact factor: 11.454

Review 9.  Four decades of continuing innovation with fluorouracil: current and future approaches to fluorouracil chemoradiation therapy.

Authors:  Tyvin A Rich; Robert C Shepard; Stephen T Mosley
Journal:  J Clin Oncol       Date:  2004-06-01       Impact factor: 44.544

10.  Therapeutic properties of a vector carrying the HSV thymidine kinase and GM-CSF genes and delivered as a complex with a cationic copolymer.

Authors:  Irina V Alekseenko; Eugene V Snezhkov; Igor P Chernov; Victor V Pleshkan; Victor K Potapov; Alexander V Sass; Galina S Monastyrskaya; Eugene P Kopantzev; Tatyana V Vinogradova; Yuri V Khramtsov; Alexey V Ulasov; Andrey A Rosenkranz; Alexander S Sobolev; Olga A Bezborodova; Anna D Plyutinskaya; Elena R Nemtsova; Raisa I Yakubovskaya; Eugene D Sverdlov
Journal:  J Transl Med       Date:  2015-03-04       Impact factor: 5.531
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.