Mathilde Boulanger1,2,3, Séverine Tual4,5,6, Clémentine Lemarchand4,5, Anne-Valérie Guizard4,7, Michel Velten8, Elisabeth Marcotullio9, Isabelle Baldi10,11,12, Bénédicte Clin4,5,13, Pierre Lebailly4,5,6. 1. UMR 1086 Cancers et Préventions, INSERM, Caen, France. mathilde.boulanger@unicaen.fr. 2. Université de Caen Normandie, Caen, France. mathilde.boulanger@unicaen.fr. 3. CHU de Caen, Service de Pathologie Professionnelle, Caen, France. mathilde.boulanger@unicaen.fr. 4. UMR 1086 Cancers et Préventions, INSERM, Caen, France. 5. Université de Caen Normandie, Caen, France. 6. Centre de Lutte Contre le Cancer François Baclesse, Caen, France. 7. Registre Général des Tumeurs du Calvados, Centre François Baclesse, Caen, France. 8. Registre des Cancers du Bas-Rhin, Faculté de Médecine, Université de Strasbourg, Strasbourg, France. 9. Caisse Centrale de la Mutualité Sociale Agricole, Echelon National Santé sécurité au travail, Bagnolet, France. 10. ISPED, Laboratoire Santé Travail Environnement, Université de Bordeaux, Bordeaux, France. 11. INSERM, ISPED, Centre INSERM U897 - Epidémiologie-Biostatistique, Bordeaux, France. 12. CHU de Bordeaux, Service de Médecine du Travail, Bordeaux, France. 13. CHU de Caen, Service de Pathologie Professionnelle, Caen, France.
Abstract
PURPOSE: Literature on agricultural activities and bladder cancer risk is scarce. However, farmers can be subjected to carcinogenic exposure (e.g. arsenic, previously used as a pesticide in France). This study aimed at assessing the role of a large range of agricultural activities and tasks on bladder cancer risk. METHODS: The study population was the AGRIculture and CANcer cohort, a large prospective cohort of individuals affiliated to the agricultural health insurance scheme (MSA) in France. Incident bladder cancers were identified by cancer registries from enrolment (2005-2007) to 2009. Data on agricultural exposure during professional lifetime (5 animals, 13 crops, specific tasks) were obtained from the enrolment questionnaire. Associations between bladder cancer and agricultural exposure were analysed using a Cox model, adjusted for gender and smoking history. RESULTS: Among the 148,051 farm owners and workers included in this analysis, 179 incident bladder cancers were identified. We observed an elevated risk among field-grown vegetable workers [HR 1.89, 95% CI (1.20-2.99)], with an exposure-response relationship with duration of work [≥30 years: HR 2.54, 95% CI (1.11-5.83), p-trend = 0.02], and higher risk among women [HR 3.82, 95% CI (1.58-9.25), p-interaction = 0.05]. Non-significantly increased risks were also observed in greenhouse farmers (HR = 1.95), pea sowing (HR = 1.84), rape sowing (HR = 1.64); several tasks involving pesticide use, especially seed treatment (HR = 1.24); and in activities and tasks potentially exposing to arsenic compounds via pesticide use (HR = 1.49) or re-entry tasks (HR = 1.63). CONCLUSIONS: Our analyses raise the question of a possible link between agricultural activity, especially field-grown vegetables, and greenhouse cultivation and bladder cancer.
PURPOSE: Literature on agricultural activities and bladder cancer risk is scarce. However, farmers can be subjected to carcinogenic exposure (e.g. arsenic, previously used as a pesticide in France). This study aimed at assessing the role of a large range of agricultural activities and tasks on bladder cancer risk. METHODS: The study population was the AGRIculture and CANcer cohort, a large prospective cohort of individuals affiliated to the agricultural health insurance scheme (MSA) in France. Incident bladder cancers were identified by cancer registries from enrolment (2005-2007) to 2009. Data on agricultural exposure during professional lifetime (5 animals, 13 crops, specific tasks) were obtained from the enrolment questionnaire. Associations between bladder cancer and agricultural exposure were analysed using a Cox model, adjusted for gender and smoking history. RESULTS: Among the 148,051 farm owners and workers included in this analysis, 179 incident bladder cancers were identified. We observed an elevated risk among field-grown vegetable workers [HR 1.89, 95% CI (1.20-2.99)], with an exposure-response relationship with duration of work [≥30 years: HR 2.54, 95% CI (1.11-5.83), p-trend = 0.02], and higher risk among women [HR 3.82, 95% CI (1.58-9.25), p-interaction = 0.05]. Non-significantly increased risks were also observed in greenhouse farmers (HR = 1.95), pea sowing (HR = 1.84), rape sowing (HR = 1.64); several tasks involving pesticide use, especially seed treatment (HR = 1.24); and in activities and tasks potentially exposing to arsenic compounds via pesticide use (HR = 1.49) or re-entry tasks (HR = 1.63). CONCLUSIONS: Our analyses raise the question of a possible link between agricultural activity, especially field-grown vegetables, and greenhouse cultivation and bladder cancer.
Authors: Laura E Beane Freeman; Anneclaire J Deroos; Stella Koutros; Aaron Blair; Mary H Ward; Michael Alavanja; Jane A Hoppin Journal: Cancer Causes Control Date: 2012-03-10 Impact factor: 2.506
Authors: Maximilian Burger; James W F Catto; Guido Dalbagni; H Barton Grossman; Harry Herr; Pierre Karakiewicz; Wassim Kassouf; Lambertus A Kiemeney; Carlo La Vecchia; Shahrokh Shariat; Yair Lotan Journal: Eur Urol Date: 2012-07-25 Impact factor: 20.096
Authors: Stella Koutros; Debra T Silverman; Michael Cr Alavanja; Gabriella Andreotti; Catherine C Lerro; Sonya Heltshe; Charles F Lynch; Dale P Sandler; Aaron Blair; Laura E Beane Freeman Journal: Int J Epidemiol Date: 2015-09-27 Impact factor: 7.196
Authors: Thays Millena Alves Pedroso; Marcelino Benvindo-Souza; Felipe de Araújo Nascimento; Júlia Woch; Fabiana Gonçalves Dos Reis; Daniela de Melo E Silva Journal: Environ Sci Pollut Res Int Date: 2021-10-19 Impact factor: 5.190