Francesco Semeraro1, Eliana Forbice1, Giuseppe Nascimbeni1, Marco Taglietti2, Vito Romano3, Germano Guerra4, Ciro Costagliola5,6. 1. Opthamology Clinic, Depatment of Medical and Surgical Specialties, Radiological Specialties and Public Health, University of Brescia, Brescia, Italy. 2. Rheumatology and Clinical Immunology Unit, University of Brescia, Brescia, Italy. 3. Department of Corneal and External Eye Diseases, St. Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, U.K. vito.romano@gmail.com. 4. Anatomy Institute, Department of Medicine & Health Sciences, University of Molise, Campobasso, Italy. 5. Eye Clinic, Department of Medicine & Health Sciences, University of Molise, Campobasso, Italy. 6. IRCCS Neuromed, Pozzilli, Isernia, Italy.
Abstract
AIM: To evaluate in vivo changes after therapy using autologous serum (AS) eye drops in Sjögren's syndrome (SS)-related dry eyes by confocal microscopy. PATIENTS AND METHODS: In this study, 24 patients with SS-related dry eyes [12 in AS eye drop therapy and 12 in artificial tear (AT) therapy] and 24 healthy volunteers were recruited. Ocular Surface Disease Index (OSDI), central corneal thickness, tear film, break-up time, corneal and conjunctival staining, Schirmer's test and corneal confocal microscopy were investigated. RESULTS:Tear production, tear stability, corneal staining, inflammation, and central corneal thickness, Langherans cells, activated keratocytes, intermediate epithelial cell density, nerve tortuosity, number of sub-basal nerve branches, and number of bead-like formations differed between patients and controls (p<0.0001). The AT and AS groups differed in the OSDI, number of branches, and number of beadings (p<0.0001). CONCLUSION: AS eye drops improve symptoms and confocal microscopy findings in SS-related dry eyes.
RCT Entities:
AIM: To evaluate in vivo changes after therapy using autologous serum (AS) eye drops in Sjögren's syndrome (SS)-related dry eyes by confocal microscopy. PATIENTS AND METHODS: In this study, 24 patients with SS-related dry eyes [12 in AS eye drop therapy and 12 in artificial tear (AT) therapy] and 24 healthy volunteers were recruited. Ocular Surface Disease Index (OSDI), central corneal thickness, tear film, break-up time, corneal and conjunctival staining, Schirmer's test and corneal confocal microscopy were investigated. RESULTS: Tear production, tear stability, corneal staining, inflammation, and central corneal thickness, Langherans cells, activated keratocytes, intermediate epithelial cell density, nerve tortuosity, number of sub-basal nerve branches, and number of bead-like formations differed between patients and controls (p<0.0001). The AT and AS groups differed in the OSDI, number of branches, and number of beadings (p<0.0001). CONCLUSION: AS eye drops improve symptoms and confocal microscopy findings in SS-related dry eyes.
Authors: Maria Luisa Pérez; Saúl Barreales; Noelia Sabater-Cruz; Eva Maria Martinez-Conesa; Anna Vilarrodona; Ricardo P Casaroli-Marano Journal: Cell Tissue Bank Date: 2021-09-21 Impact factor: 1.752
Authors: Eirini Nitoda; Anastasios Lavaris; Konstantinos Laios; Sophia Androudi; Chris D Kalogeropoulos; Michael Tsatsos; Christos Damaskos; Nikolaos Garmpis; Marilita M Moschos Journal: In Vivo Date: 2018 Mar-Apr Impact factor: 2.155