Cirlene de Lima Marinho1, Maria Christina Paixão Maioli2, Andrea Ribeiro Soares2, Ricardo Bedirian3, Pedro Lopes de Melo4, Fernando Silva Guimarães5, Arthur de Sá Ferreira5, Agnaldo José Lopes6. 1. Post-graduate Program in Clinical and Experimental Physiopathology, School of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil. 2. Hematology Department, State University of Rio de Janeiro, Rio de Janeiro, Brazil; Post-graduate Program in Medical Sciences, School of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil. 3. Post-graduate Program in Medical Sciences, School of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil. 4. Post-graduate Program in Clinical and Experimental Physiopathology, School of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil; Post-graduate Program in Medical Sciences, School of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil; Biomedical Instrumentation Laboratory, Institute of Biology and Faculty of Engineering, State University of Rio de Janeiro, Rio de Janeiro, Brazil. 5. Rehabilitation Sciences Post-graduate Program, Augusto Motta University Center, Rio de Janeiro, Brazil. 6. Post-graduate Program in Medical Sciences, School of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil; Rehabilitation Sciences Post-graduate Program, Augusto Motta University Center, Rio de Janeiro, Brazil. Electronic address: agnaldolopes.uerj@gmail.com.
Abstract
BACKGROUND: Sickle cell anemia (SCA) is characterized by a broad spectrum of abnormalities that affect most body organs and systems. To date, there is few data on the influence of these patients' clinical characteristics on the functional exercise capacity. AIM: To investigate the effect of the clinical complications on the functional exercise capacity of adult SCA patients. METHOD: Cross-sectional study, where 45 SCA patients underwent clinical evaluations, echocardiography, pulmonary function testing, and determination of six-minute walking distance (6MWD). RESULTS: A significant correlation (P < 0.001) was found between 6MWD and hemoglobin (Hb) level, tricuspid regurgitation velocity, forced vital capacity, acute chest syndrome, and diffusing capacity for carbon monoxide. The prediction model for 6MWD explained 67% of the 6MWD variability (P < 0.001). CONCLUSIONS: Hemodynamics, cardiovascular function, pulmonary function, and episodes of acute lung injury seem to impact the 6MWD in adults with SCA.
BACKGROUND:Sickle cell anemia (SCA) is characterized by a broad spectrum of abnormalities that affect most body organs and systems. To date, there is few data on the influence of these patients' clinical characteristics on the functional exercise capacity. AIM: To investigate the effect of the clinical complications on the functional exercise capacity of adult SCApatients. METHOD: Cross-sectional study, where 45 SCApatients underwent clinical evaluations, echocardiography, pulmonary function testing, and determination of six-minute walking distance (6MWD). RESULTS: A significant correlation (P < 0.001) was found between 6MWD and hemoglobin (Hb) level, tricuspid regurgitation velocity, forced vital capacity, acute chest syndrome, and diffusing capacity for carbon monoxide. The prediction model for 6MWD explained 67% of the 6MWD variability (P < 0.001). CONCLUSIONS: Hemodynamics, cardiovascular function, pulmonary function, and episodes of acute lung injury seem to impact the 6MWD in adults with SCA.
Authors: Charles R Jonassaint; Amit Birenboim; Dana Rae Jorgensen; Enrico M Novelli; Andrea L Rosso Journal: Br J Haematol Date: 2017-07-17 Impact factor: 6.998
Authors: A J Lopes; C L Marinho; U D Alves; C E A Gonçalves; P O Silva; E C Botelho; R Bedirian; A R Soares; M C P Maioli Journal: Braz J Med Biol Res Date: 2017-07-20 Impact factor: 2.590
Authors: Cirlene de Lima Marinho; Maria Christina Paixão Maioli; Jorge Luis Machado do Amaral; Agnaldo José Lopes; Pedro Lopes de Melo Journal: PLoS One Date: 2019-03-07 Impact factor: 3.240
Authors: Kellsey N Smith; Tracy Baynard; Peter S Fischbach; Jane S Hankins; Lewis L Hsu; Peggy M Murphy; Kiri K Ness; Shlomit Radom-Aizik; Amy Tang; Robert I Liem Journal: Br J Sports Med Date: 2021-07-20 Impact factor: 18.473