Literature DB >> 27814519

The Human Functional Genomics Project: Understanding Generation of Diversity.

Jenna L Pappalardo1, David A Hafler2.   

Abstract

Generation of biologic diversity is a cornerstone of immunity, yet the tools to investigate the causal influence of genetic and environmental factors have been greatly limited. Studies from the Human Functional Genomics Project, presented in Cell and other Cell Press journals, integrate environmental and genetic factors with the direction and magnitude of immune responses to decipher inflammatory disease pathogenesis.
Copyright © 2016 Elsevier Inc. All rights reserved.

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Year:  2016        PMID： 27814519     DOI： 10.1016/j.cell.2016.10.040

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  3 in total

1.  Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease.

Authors:  Xiaojing Chu; Martin Jaeger; Cisca Wijmenga; Mihai G Netea; Yang Li; Joep Beumer; Olivier B Bakker; Raul Aguirre-Gamboa; Marije Oosting; Sanne P Smeekens; Simone Moorlag; Vera P Mourits; Valerie A C M Koeken; Charlotte de Bree; Trees Jansen; Ian T Mathews; Khoi Dao; Mahan Najhawan; Jeramie D Watrous; Irma Joosten; Sonia Sharma; Hans J P M Koenen; Sebo Withoff; Iris H Jonkers; Romana T Netea-Maier; Ramnik J Xavier; Lude Franke; Cheng-Jian Xu; Leo A B Joosten; Serena Sanna; Mohit Jain; Vinod Kumar; Hans Clevers
Journal:  Genome Biol       Date:  2021-07-06       Impact factor: 13.583

2.  Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity.

Authors:  Tomokazu Sumida; Matthew R Lincoln; Chinonso M Ukeje; Donald M Rodriguez; Hiroshi Akazawa; Tetsuo Noda; Atsuhiko T Naito; Issei Komuro; Margarita Dominguez-Villar; David A Hafler
Journal:  Nat Immunol       Date:  2018-10-29       Impact factor: 25.606

Review 3.  Milieu intérieur: Defining the boundaries of a healthy immune response for improved vaccination strategies.

Authors:  Darragh Duffy
Journal:  Hum Vaccin Immunother       Date:  2018-07-24       Impact factor: 3.452
  3 in total

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