Literature DB >> 27813828

Receptor-Mediated Endocytosis in the Proximal Tubule.

Megan L Eshbach1, Ora A Weisz1.   

Abstract

Cells lining the proximal tubule (PT) of the kidney are highly specialized for apical endocytosis of filtered proteins and small bioactive molecules from the glomerular ultrafiltrate to maintain essentially protein-free urine. Compromise of this pathway results in low molecular weight (LMW) proteinuria that can progress to end-stage kidney disease. This review describes our current understanding of the endocytic pathway and the multiligand receptors that mediate LMW protein uptake in PT cells, how these are regulated in response to physiologic cues, and the molecular basis of inherited diseases characterized by LMW proteinuria.

Entities:  

Keywords:  Dent disease; Lowe syndrome; albumin; apical; cubilin; cystinosis; kidney; megalin; proteinuria

Mesh：

Substances：

Year:  2016        PMID： 27813828      PMCID： PMC5512543          DOI： 10.1146/annurev-physiol-022516-034234

Source DB:  PubMed          Journal:  Annu Rev Physiol        ISSN： 0066-4278            Impact factor:   19.318


  148 in total

1.  Transforming growth factor-beta1 reduces megalin- and cubilin-mediated endocytosis of albumin in proximal-tubule-derived opossum kidney cells.

Authors:  Michael Gekle; Petra Knaus; Rikke Nielsen; Sigrid Mildenberger; Ruth Freudinger; Verena Wohlfarth; Christoph Sauvant; Erik I Christensen
Journal:  J Physiol       Date:  2003-10-15       Impact factor: 5.182

2.  Altered renal proximal tubular endocytosis and histology in mice lacking myosin-VI.

Authors:  Nanami Gotoh; Qingshang Yan; Zhaopeng Du; Daniel Biemesderfer; Michael Kashgarian; Mark S Mooseker; Tong Wang
Journal:  Cytoskeleton (Hoboken)       Date:  2010-03

3.  Mouse model for Lowe syndrome/Dent Disease 2 renal tubulopathy.

Authors:  Susan P Bothwell; Emily Chan; Isa M Bernardini; Yien-Ming Kuo; William A Gahl; Robert L Nussbaum
Journal:  J Am Soc Nephrol       Date:  2010-12-23       Impact factor: 10.121

4.  Rab11a-positive compartments in proximal tubule cells sort fluid-phase and membrane cargo.

Authors:  Polly E Mattila; Venkatesan Raghavan; Youssef Rbaibi; Catherine J Baty; Ora A Weisz
Journal:  Am J Physiol Cell Physiol       Date:  2013-10-23       Impact factor: 4.249

5.  Albumin endocytosis in proximal tubule cells is modulated by angiotensin II through an AT2 receptor-mediated protein kinase B activation.

Authors:  Celso Caruso-Neves; Sang-Ho Kwon; William B Guggino
Journal:  Proc Natl Acad Sci U S A       Date:  2005-11-17       Impact factor: 11.205

6.  Akt recruits Dab2 to albumin endocytosis in the proximal tubule.

Authors:  Kelly Koral; Hui Li; Nandita Ganesh; Morris J Birnbaum; Kenneth R Hallows; Elif Erkan
Journal:  Am J Physiol Renal Physiol       Date:  2014-09-24

7.  Regulation of tight junction assembly and epithelial polarity by a resident protein of apical endosomes.

Authors:  Sarah D McCarter; Debra L Johnson; Khameeka N Kitt; Carolyn Donohue; Alison Adams; Jean M Wilson
Journal:  Traffic       Date:  2010-02-27       Impact factor: 6.215

8.  Megalin is downregulated via LPS-TNF-α-ERK1/2 signaling pathway in proximal tubule cells.

Authors:  Aya Takeyama; Hiroyoshi Sato; Taeko Soma-Nagae; Hideyuki Kabasawa; Akiyo Suzuki; Keiko Yamamoto-Kabasawa; Michihiro Hosojima; Reika Kaneko; Fumie Higuchi; Ryohei Kaseda; Shinya Ogasawara; Ichiei Narita; Akihiko Saito
Journal:  Biochem Biophys Res Commun       Date:  2011-02-28       Impact factor: 3.575

9.  Interactions of cubilin with megalin and the product of the amnionless gene (AMN): effect on its stability.

Authors:  Rajiv Ahuja; Raghunatha Yammani; Joseph A Bauer; Seema Kalra; Shakuntla Seetharam; Bellur Seetharam
Journal:  Biochem J       Date:  2008-03-01       Impact factor: 3.857

10.  A role of OCRL in clathrin-coated pit dynamics and uncoating revealed by studies of Lowe syndrome cells.

Authors:  Ramiro Nández; Daniel M Balkin; Mirko Messa; Liang Liang; Summer Paradise; Heather Czapla; Marco Y Hein; James S Duncan; Matthias Mann; Pietro De Camilli
Journal:  Elife       Date:  2014-08-08       Impact factor: 8.140
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  42 in total

1.  Urine proteomic profiling in patients with nephrolithiasis and cystinuria.

Authors:  Larisa Kovacevic; Joseph A Caruso; Hong Lu; Natalija Kovacevic; Yegappan Lakshmanan; Nicholas J Carruthers; David S Goldfarb
Journal:  Int Urol Nephrol       Date:  2018-12-05       Impact factor: 2.370

2.  Immunohistochemical localization of megalin and cubilin in the human inner ear.

Authors:  Seiji Hosokawa; Kumiko Hosokawa; Gail Ishiyama; Akira Ishiyama; Ivan A Lopez
Journal:  Brain Res       Date:  2018-09-12       Impact factor: 3.252

3.  Combined Structural and Functional Imaging of the Kidney Reveals Major Axial Differences in Proximal Tubule Endocytosis.

Authors:  Claus D Schuh; Marcello Polesel; Evgenia Platonova; Dominik Haenni; Alkaly Gassama; Natsuko Tokonami; Susan Ghazi; Milica Bugarski; Olivier Devuyst; Urs Ziegler; Andrew M Hall
Journal:  J Am Soc Nephrol       Date:  2018-10-09       Impact factor: 10.121

Review 4.  Endocytic receptor LRP2/megalin-of holoprosencephaly and renal Fanconi syndrome.

Authors:  Thomas E Willnow; Annabel Christ
Journal:  Pflugers Arch       Date:  2017-05-11       Impact factor: 3.657

5.  Hemoglobin inhibits albumin uptake by proximal tubule cells: implications for sickle cell disease.

Authors:  Megan L Eshbach; Amandeep Kaur; Youssef Rbaibi; Jesús Tejero; Ora A Weisz
Journal:  Am J Physiol Cell Physiol       Date:  2017-03-29       Impact factor: 4.249

Review 6.  Rescuing the Last-Line Polymyxins: Achievements and Challenges.

Authors:  Sue C Nang; Mohammad A K Azad; Tony Velkov; Qi Tony Zhou; Jian Li
Journal:  Pharmacol Rev       Date:  2021-04       Impact factor: 25.468

7.  Differential kidney proximal tubule cell responses to protein overload by albumin and its ligands.

Authors:  Kimberly R Long; Youssef Rbaibi; Megan L Gliozzi; Qidong Ren; Ora A Weisz
Journal:  Am J Physiol Renal Physiol       Date:  2020-02-18

8.  Protection of Cystinotic Mice by Kidney-Specific Megalin Ablation Supports an Endocytosis-Based Mechanism for Nephropathic Cystinosis Progression.

Authors:  Virginie Janssens; Héloïse P Gaide Chevronnay; Sandrine Marie; Marie-Françoise Vincent; Patrick Van Der Smissen; Nathalie Nevo; Seppo Vainio; Rikke Nielsen; Erik I Christensen; François Jouret; Corinne Antignac; Christophe E Pierreux; Pierre J Courtoy
Journal:  J Am Soc Nephrol       Date:  2019-09-23       Impact factor: 10.121

9.  Distinct functions of megalin and cubilin receptors in recovery of normal and nephrotic levels of filtered albumin.

Authors:  Qidong Ren; Kathrin Weyer; Youssef Rbaibi; Kimberly R Long; Roderick J Tan; Rikke Nielsen; Erik I Christensen; Catherine J Baty; Ossama B Kashlan; Ora A Weisz
Journal:  Am J Physiol Renal Physiol       Date:  2020-03-23

10.  Hemoglobin alters vitamin carrier uptake and vitamin D metabolism in proximal tubule cells: implications for sickle cell disease.

Authors:  Megan L Gliozzi; Youssef Rbaibi; Kimberly R Long; Dario A Vitturi; Ora A Weisz
Journal:  Am J Physiol Cell Physiol       Date:  2019-09-11       Impact factor: 4.249
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