Literature DB >> 27813702

Early diagnosis and effective treatment regimens are the keys to tackle antimicrobial resistance in tuberculosis (TB): A report from Euroscicon's international TB Summit 2016.

Arundhati Maitra1, Tengku Karmila Kamil1, Monisha Shaik1, Cynthia Amaning Danquah1, Alina Chrzastek1, Sanjib Bhakta1.   

Abstract

To say that tuberculosis (TB) has regained a strong foothold in the global human health and wellbeing scenario would be an understatement. Ranking alongside HIV/AIDS as the top reason for mortality due to a single infectious disease, the impact of TB extends far into socio-economic context worldwide. As global efforts led by experts and political bodies converge to mitigate the predicted outcome of growing antimicrobial resistance, the academic community of students, practitioners and researchers have mobilised to develop integrated, inter-disciplinary programmes to bring the plans of the former to fruition. Enabling this crucial requirement for unimpeded dissemination of scientific discovery was the TB Summit 2016, held in London, United Kingdom. This report critically discusses the recent breakthroughs made in diagnostics and treatment while bringing to light the major hurdles in the control of the disease as discussed in the course of the 3-day international event. Conferences and symposia such as these are the breeding grounds for successful local and global collaborations and therefore must be supported to expand the understanding and outreach of basic science research.

Entities:  

Keywords:  antibiotics; drug-discovery; drug-resistance; drug-susceptibility testing; tuberculosis

Mesh:

Substances:

Year:  2016        PMID: 27813702      PMCID: PMC5626228          DOI: 10.1080/21505594.2016.1256536

Source DB:  PubMed          Journal:  Virulence        ISSN: 2150-5594            Impact factor:   5.882


  131 in total

Review 1.  Microbial pathogenesis of Mycobacterium tuberculosis: dawn of a discipline.

Authors:  M S Glickman; W R Jacobs
Journal:  Cell       Date:  2001-02-23       Impact factor: 41.582

2.  Loop-mediated isothermal amplification of DNA.

Authors:  T Notomi; H Okayama; H Masubuchi; T Yonekawa; K Watanabe; N Amino; T Hase
Journal:  Nucleic Acids Res       Date:  2000-06-15       Impact factor: 16.971

3.  Structural, functional, and genetic analyses of the actinobacterial transcription factor RbpA.

Authors:  Elizabeth A Hubin; Aline Tabib-Salazar; Laurence J Humphrey; Joshua E Flack; Paul Dominic B Olinares; Seth A Darst; Elizabeth A Campbell; Mark S Paget
Journal:  Proc Natl Acad Sci U S A       Date:  2015-05-26       Impact factor: 11.205

4.  Pulse Proteolysis and Precipitation for Target Identification.

Authors:  Rogério V Trindade; Antônio F M Pinto; Diógenes S Santos; Cristiano V Bizarro
Journal:  J Proteome Res       Date:  2016-06-20       Impact factor: 4.466

5.  Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824.

Authors:  Xiaojin Li; Ujjini H Manjunatha; Michael B Goodwin; John E Knox; Christopher A Lipinski; Thomas H Keller; Clifton E Barry; Cynthia S Dowd
Journal:  Bioorg Med Chem Lett       Date:  2008-03-07       Impact factor: 2.823

6.  Phenylbutyrate induces LL-37-dependent autophagy and intracellular killing of Mycobacterium tuberculosis in human macrophages.

Authors:  Rokeya Sultana Rekha; S S V Jagadeeswara Rao Muvva; Min Wan; Rubhana Raqib; Peter Bergman; Susanna Brighenti; Gudmundur H Gudmundsson; Birgitta Agerberth
Journal:  Autophagy       Date:  2015       Impact factor: 16.016

Review 7.  Human immunity to M. tuberculosis: T cell subsets and antigen processing.

Authors:  W H Boom; David H Canaday; Scott A Fulton; Adam J Gehring; Roxana E Rojas; Marta Torres
Journal:  Tuberculosis (Edinb)       Date:  2003       Impact factor: 3.131

8.  Epidemiological and clinical patterns of intrathoracic lymph node tuberculosis in 60 human immunodeficiency virus-negative adult patients.

Authors:  L R Codecasa; G Besozzi; L De Cristofaro; A Miradoli; L Sabolla; B Tagliaferri
Journal:  Monaldi Arch Chest Dis       Date:  1998-06

9.  Genes required for mycobacterial growth defined by high density mutagenesis.

Authors:  Christopher M Sassetti; Dana H Boyd; Eric J Rubin
Journal:  Mol Microbiol       Date:  2003-04       Impact factor: 3.501

10.  Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy.

Authors:  Isobella Honeyborne; Timothy D McHugh; Iitu Kuittinen; Anna Cichonska; Dimitrios Evangelopoulos; Katharina Ronacher; Paul D van Helden; Stephen H Gillespie; Delmiro Fernandez-Reyes; Gerhard Walzl; Juho Rousu; Philip D Butcher; Simon J Waddell
Journal:  BMC Med       Date:  2016-04-07       Impact factor: 8.775

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  5 in total

1.  Comparative Profiling of Circulating Exosomal Small RNAs Derived From Peruvian Patients With Tuberculosis and Pulmonary Adenocarcinoma.

Authors:  Heinner Guio; Victor Aliaga-Tobar; Marco Galarza; Oscar Pellon-Cardenas; Silvia Capristano; Henry L Gomez; Mivael Olivera; Cesar Sanchez; Vinicius Maracaja-Coutinho
Journal:  Front Cell Infect Microbiol       Date:  2022-06-30       Impact factor: 6.073

Review 2.  Host Antimicrobial Peptides: The Promise of New Treatment Strategies against Tuberculosis.

Authors:  Javier Arranz-Trullén; Lu Lu; David Pulido; Sanjib Bhakta; Ester Boix
Journal:  Front Immunol       Date:  2017-11-07       Impact factor: 7.561

3.  Human Antimicrobial RNases Inhibit Intracellular Bacterial Growth and Induce Autophagy in Mycobacteria-Infected Macrophages.

Authors:  Lu Lu; Javier Arranz-Trullén; Guillem Prats-Ejarque; David Pulido; Sanjib Bhakta; Ester Boix
Journal:  Front Immunol       Date:  2019-07-02       Impact factor: 7.561

4.  Identification of MicroRNAs as Potential Blood-Based Biomarkers for Diagnosis and Therapeutic Monitoring of Active Tuberculosis.

Authors:  Junseong Kim; Heechul Park; Sung-Bae Park; Eun Ju Lee; Min-A Je; Eunsol Ahn; Bora Sim; Jiyoung Lee; Hyunwoo Jin; Kyung Eun Lee; Sang-Nae Cho; Young Ae Kang; Hyejon Lee; Sunghyun Kim; Jungho Kim
Journal:  Diagnostics (Basel)       Date:  2022-02-01

5.  Improving Assignments for Therapeutic and Prophylactic Treatment Within TB Households. A Potential for Immuno-Diagnosis?

Authors:  Dhanasekaran Sivakumaran; Synne Jenum; Christian Ritz; Mario Vaz; Timothy Mark Doherty; Harleen M S Grewal
Journal:  Front Immunol       Date:  2022-03-17       Impact factor: 7.561

  5 in total

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