| Literature DB >> 27813305 |
Filippos Triposkiadis1, Burkert Pieske2, Javed Butler3, John Parissis4, Gregory Giamouzis5, John Skoularigis5, Dirk Brutsaert6, Harisios Boudoulas7,8.
Abstract
The left atrium plays an important role in the maintenance of cardiovascular and neurohumoral homeostasis in heart failure. However, with progressive left ventricular dysfunction, left atrial (LA) dilation and mechanical failure develop, which frequently culminate in atrial fibrillation. Moreover, LA mechanical failure is accompanied by LA endocrine failure [deficient atrial natriuretic peptide (ANP) processing-synthesis/development of ANP resistance) and LA regulatory failure (dominance of sympathetic nervous system excitatory mechanisms, excessive vasopressin release) contributing to neurohumoral overactivity, vasoconstriction, and volume overload (global LA failure). The purpose of the present review is to describe the characteristics and emphasize the clinical significance of global LA failure in patients with heart failure.Entities:
Keywords: Dilatation; Heart failure; Left atrium; Natriuretic peptide
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Year: 2016 PMID： 27813305 DOI： 10.1002/ejhf.645
Source DB: PubMed Journal: Eur J Heart Fail ISSN： 1388-9842 Impact factor: 15.534