Literature DB >> 27811320

Cross-Reactive and Cross-Neutralizing Activity of Human Mumps Antibodies Against a Novel Mumps Virus From Bats.

Shannon M Beaty1, Raffael Nachbagauer1, Ariana Hirsh1, Frederic Vigant1, James Duehr1, Kristopher D Azarm1, Alice J Stelfox2, Thomas A Bowden2, W Paul Duprex3, Florian Krammer1, Benhur Lee1.   

Abstract

To evaluate the antigenic relationship between bat mumps virus (BMV) and the JL5 vaccine strain of mumps virus (MuVJL5), we rescued a chimeric virus bearing the F and HN glycoproteins of BMV in the background of a recombinant JL5 genome (rMuVJL5). Cross-reactivity and cross-neutralization between this chimeric recombinant MuV bearing the F and HN glycoproteins of BMV (rMuVJL5-F/HNBMV) virus and rMuVJL5 were demonstrated using hyperimmune mouse serum samples and a curated panel of human serum. All mouse and human serum samples that were able to neutralize rMuVJL5 infection had cross-neutralizing activity against rMuVJL5-F/HNBMV. Our data suggest that persons who have neutralizing antibodies against MuV might be protected from infection by BMV.
© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

Entities:  

Keywords:  cross-reactive antibodies; mumps virus; neutralizing antibodies; viral envelope proteins; zoonoses

Mesh：

Substances：

Year:  2017        PMID： 27811320      PMCID： PMC5854012          DOI： 10.1093/infdis/jiw534

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  14 in total

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3.  Characterization of genotype-specific epitopes of the HN protein of mumps virus.

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4.  Functional properties and genetic relatedness of the fusion and hemagglutinin-neuraminidase proteins of a mumps virus-like bat virus.

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Authors:  A M Galazka; S E Robertson; A Kraigher
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9.  Bats host major mammalian paramyxoviruses.

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Journal:  Nat Commun       Date:  2012-04-24       Impact factor: 14.919

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Review 2.  Zoonotic Potential of Emerging Paramyxoviruses: Knowns and Unknowns.

Authors:  Patricia A Thibault; Ruth E Watkinson; Andres Moreira-Soto; Jan F Drexler; Benhur Lee
Journal:  Adv Virus Res       Date:  2017-02-02       Impact factor: 9.937

3.  Co-Circulation and Excretion Dynamics of Diverse Rubula- and Related Viruses in Egyptian Rousette Bats from South Africa.

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4.  Genome-wide transposon mutagenesis of paramyxoviruses reveals constraints on genomic plasticity.

Authors:  Satoshi Ikegame; Shannon M Beaty; Christian Stevens; Taylor Won; Arnold Park; David Sachs; Patrick Hong; Benhur Lee; Patricia A Thibault
Journal:  PLoS Pathog       Date:  2020-10-09       Impact factor: 6.823

Review 5.  Viruses in bats and potential spillover to animals and humans.

Authors:  Lin-Fa Wang; Danielle E Anderson
Journal:  Curr Opin Virol       Date:  2019-01-18       Impact factor: 7.090
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