Makoto Ohara1, Tomoyasu Fukui2, Motoshi Ouchi3, Kentaro Watanabe4, Tatsuya Suzuki5, Saki Yamamoto2, Takeshi Yamamoto2, Toshiyuki Hayashi2, Kenzo Oba6, Tsutomu Hirano2. 1. Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, Japan. Electronic address: s6018@nms.ac.jp. 2. Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, Japan. 3. Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Japan. 4. Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology (DNHMED), Yamagata University Faculty of Medicine, Japan. 5. Division of Geriatric Medicine, Nippon Medical School, Japan. 6. Department of Internal Medicine, Oarai Coast Core Clinic, Japan.
Abstract
AIMS: To determine the association of daily and day-to-day glucose variability with oxidative stress. METHODS: This was a cross-sectional analysis of 68 patients with type 2 diabetes mellitus (T2DM) over 72h of continuous glucose monitoring. Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) were measured before breakfast on day 1. Glucose variability, mean glucose level (MGL), mean amplitude of glycemic excursions (MAGE), mean of daily differences (MODD) in glucose levels and area under the postprandial plasma glucose curve (AUCPP) were measured on days 2 and 3. Plasma oxidant capacity against N,N-diethylparaphenylenediamine was measured with the diacron-reactive oxygen metabolites (d-ROMs) test on day 1. RESULTS: Overall, 66.2% males with the mean age of 63.2±12.6years, diabetes duration of 12.9±10.4years, and HbA1c level of 8.1±1.6% (65±17mmol/mol) were included. MGL (r=0.330), HbA1c (r=0.326), MAGE (r=0.565), MODD (r=0.488), and AUCPP (r=0.254) exhibited significant correlations with d-ROMs and not FPG; these correlations remained significant after adjustment for clinical factors (sex, age, duration of diabetes, smoking habit, insulin use, statin use, angiotensin II receptor blocker use, BMI, LDL-C, HDL-C, TG, eGFR, and systolic blood pressure) (R2=0.268, R2=0.268, R2=0.417, R2=0.314, and R2=0.347, respectively). MAGE was significantly correlated with MODD (r=0.708) and MAGE and MODD were independently correlated with d-ROMs by multivariate analysis. CONCLUSIONS: Therefore, oxidative stress is associated with daily and day-to-day glucose variability in patients with T2DM.
AIMS: To determine the association of daily and day-to-day glucose variability with oxidative stress. METHODS: This was a cross-sectional analysis of 68 patients with type 2 diabetes mellitus (T2DM) over 72h of continuous glucose monitoring. Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) were measured before breakfast on day 1. Glucose variability, mean glucose level (MGL), mean amplitude of glycemic excursions (MAGE), mean of daily differences (MODD) in glucose levels and area under the postprandial plasma glucose curve (AUCPP) were measured on days 2 and 3. Plasma oxidant capacity against N,N-diethylparaphenylenediamine was measured with the diacron-reactive oxygen metabolites (d-ROMs) test on day 1. RESULTS: Overall, 66.2% males with the mean age of 63.2±12.6years, diabetes duration of 12.9±10.4years, and HbA1c level of 8.1±1.6% (65±17mmol/mol) were included. MGL (r=0.330), HbA1c (r=0.326), MAGE (r=0.565), MODD (r=0.488), and AUCPP (r=0.254) exhibited significant correlations with d-ROMs and not FPG; these correlations remained significant after adjustment for clinical factors (sex, age, duration of diabetes, smoking habit, insulin use, statin use, angiotensin II receptor blocker use, BMI, LDL-C, HDL-C, TG, eGFR, and systolic blood pressure) (R2=0.268, R2=0.268, R2=0.417, R2=0.314, and R2=0.347, respectively). MAGE was significantly correlated with MODD (r=0.708) and MAGE and MODD were independently correlated with d-ROMs by multivariate analysis. CONCLUSIONS: Therefore, oxidative stress is associated with daily and day-to-day glucose variability in patients with T2DM.
Authors: Giada Acciaroli; Giovanni Sparacino; Liisa Hakaste; Andrea Facchinetti; Giorgio Maria Di Nunzio; Alessandro Palombit; Tiinamaija Tuomi; Rafael Gabriel; Jaime Aranda; Saturio Vega; Claudio Cobelli Journal: J Diabetes Sci Technol Date: 2017-06-01
Authors: Kristina M Utzschneider; Tonya N Johnson; Kara L Breymeyer; Lisa Bettcher; Daniel Raftery; Katherine M Newton; Marian L Neuhouser Journal: J Diabetes Complications Date: 2020-04-18 Impact factor: 2.852