| Literature DB >> 27810639 |
Raquel Requejo-Aguilar1, Ana Alastrue-Agudo1, Marta Cases-Villar1, Eric Lopez-Mocholi1, Richard England2, María J Vicent3, Victoria Moreno-Manzano4.
Abstract
Spinal cord injury (SCI) suffers from a lack of effective therapeutic strategies. Animal models of acute SCI have provided evidence that transplantation of ependymal stem/progenitor cells of the spinal cord (epSPCs) induces functional recovery, while systemic administration of the anti-inflammatory curcumin provides neuroprotection. However, functional recovery from chronic stage SCI requires additional enhancements in available therapeutic strategies. Herein, we report on a combination treatment for SCI using epSPCs and a pH-responsive polymer-curcumin conjugate. The incorporation of curcumin in a pH-responsive polymeric carrier mainchain, a polyacetal (PA), enhances blood bioavailability, stability, and provides a means for highly localized delivery. We find that PA-curcumin enhances neuroprotection, increases axonal growth, and can improve functional recovery in acute SCI. However, when combined with epSPCs, PA-curcumin also enhances functional recovery in a rodent model of chronic SCI. This suggests that combination therapy may be an exciting new therapeutic option for the treatment of chronic SCI in humans.Entities:
Keywords: Curcumin; Ependymal progenitor stem cells; Polymer Therapeutics; Rho kinase; Spinal cord injury
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Year: 2016 PMID： 27810639 DOI： 10.1016/j.biomaterials.2016.10.032
Source DB: PubMed Journal: Biomaterials ISSN： 0142-9612 Impact factor: 12.479